Effects of Nano-Protein Complexes on Apoptosis of Myocardial Infarction Cells Based on Complex Curve Analysis
| Autor: | Bo Yang, Ran Dong, Chang-Lin Lu, Hua Zhao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Materials science 020209 energy medicine.medical_treatment Myocardial Infarction Biomedical Engineering Ischemia Apoptosis Bioengineering 02 engineering and technology Anterior Descending Coronary Artery 01 natural sciences Rats Sprague-Dawley Internal medicine 0202 electrical engineering electronic engineering information engineering medicine Animals Humans Myocytes Cardiac General Materials Science cardiovascular diseases Myocardial infarction Thoracotomy Ventricular remodeling Saline Myocardium 010401 analytical chemistry Therapeutic effect General Chemistry Condensed Matter Physics medicine.disease Rats 0104 chemical sciences cardiovascular system Cardiology |
| Zdroj: | Journal of Nanoscience and Nanotechnology. 21:1272-1277 |
| ISSN: | 1533-4880 |
| DOI: | 10.1166/jnn.2021.18657 |
| Popis: | Myocardial infarction is one of the common types of coronary heart disease in the clinic. Its morbidity, lethality and disability are high, and it has become a serious threat to human health. At present, it is shown that in the early stage of acute myocardial infarction, myocardial cells are mainly apoptotic, suggesting that effectively blocking myocardial apoptosis in the early stage of myocardial infarction is of great significance for reducing tissue necrosis in the infarcted area. Recent studies have shown that NG nano-protein complexes have a better therapeutic effect on acute myocardial infarction and can inhibit left ventricular remodeling in patients with acute myocardial infarction. However, there are few studies on the effect of NG nano-protein complexes on myocardial cell apoptosis after ischemia. This study used a rat model of acute myocardial infarction to analyze its effect on apoptotic proteins of myocardial cells in rats with acute myocardial infarction in order to provide a certain theoretical basis for its clinical application. In this study, 45 SD rats were randomly divided into a sham operation group, a myocardial infarction group, and a NG nano-protein complex group, with 15 in each group. The sham operation group only underwent thoracotomy, and received normal saline gavage postoperatively; the myocardial infarction group and the NG nano-protein complex group were ligated to the left anterior descending coronary artery of the rat to establish an acute myocardial infarction model, and were performed separately treatment with saline and NG nanoprotein complexes. Finally, we conclude that this nano-protein complex can significantly reduce the expression level of myocardial apoptosis-related proteins in rats with acute myocardial infarction, and is of great significance in inhibiting the apoptosis of acute myocardial infarction cells. |
| Databáze: | OpenAIRE |
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