Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer
| Autor: | Joao Siufi Neto, Karen S. Anderson, Mauricio Simões Abrão, Daniela Siufi, Rosanne M. Kho, Edmund Chada Baracat |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Ovarian Neoplasms
Pathology medicine.medical_specialty Stromal cell ENDOMETRIOSE ARID1A biology business.industry Carcinoma Endometriosis Obstetrics and Gynecology medicine.disease medicine.disease_cause Pathogenesis Mutation microRNA medicine biology.protein Humans PTEN Female KRAS business Ovarian cancer |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1553-4650 |
| Popis: | Our understanding of the pathogenesis of endometriosis is rapidly evolving as early molecular events are increasingly identified. Endometriosis is associated with increased risk of ovarian cancer and exhibits neoplastic phenotypes including invasion of stromal tissue and lymphatic spread to distant organs. This review of the literature establishes the clinical, epidemiologic, and pathologic correlation between endometriosis and low-grade ovarian cancer. Genetic studies have demonstrated that endometriotic lesions have mutations in genes directly related to neoplasms, in particular the p53, KRAS, PTEN, and ARID1A genes, which suggests a direct transition from a subset of endometriotic lesions to invasive carcinomas. The identification of both genetic and epigenetic biomarkers including microRNAs are essential for identifying patients at risk for the transition to neoplasia. |
| Databáze: | OpenAIRE |
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