Mesenchymal stem cell markers in periodontal tissues and periapical lesions

Autor: Lorena Vieira Sacramento, Simone Cristina Leal Tosta Dos Santos, Águida Cristina Gomes Henriques Leitão, Jean Nunes dos Santos, Larissa Abbehusen Couto de Carvalho, Vildeman Rodrigues de Almeida Júnior, Flávia Caló Aquino Xavier
Rok vydání: 2020
Předmět:
0301 basic medicine
Homeobox protein NANOG
Pathology
medicine.medical_specialty
Regenerative Endodontics
Histology
Periodontal Ligament
Gene Expression
Regenerative medicine
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Chondrocytes
Antigens
CD
Osteogenesis
Adipocytes
Periodontal fiber
Medicine
Humans
Radiology
Nuclear Medicine and imaging
Dentistry (miscellaneous)
CD90
Cell Lineage
Dental Pulp
Dental follicle
Osteoblasts
biology
business.industry
Periapical Diseases
Mesenchymal stem cell
CD44
Cell Differentiation
Mesenchymal Stem Cells
Cell Biology
General Medicine
Nanog Homeobox Protein
030104 developmental biology
030220 oncology & carcinogenesis
Antigens
Surface
biology.protein
CD146
Surgery
Oral Surgery
business
Octamer Transcription Factor-3
Biomarkers
Zdroj: Acta histochemica. 122(8)
ISSN: 1618-0372
Popis: Introduction Mesenchymal stem cells (MSCs) are characterized by the potential to differentiate into multiple cell lineages, high proliferation rates, and self-renewal capacity, in addition to the ability to maintain their undifferentiated state. These cells have been identified in physiological oral tissues such as pulp tissue, dental follicle, apical papilla and periodontal ligament, as well as in pathological situations such as chronic periapical lesions (CPLs). The criteria used for the identification of MSCs include the positive expression of specific surface antigens, with CD73, CD90, CD105, CD44, CD146, STRO-1, CD166, NANOG and OCT4 being the most specific for these cells. Aim The aim of this review was to explore the literature on markers able to identify MSCs as well as the presence of these cells in the healthy periodontal ligament and CPLs, highlighting their role in regenerative medicine and implications in the progression of these lesions. Methods Narrative literature review searching the PubMed and Medline databases. Articles published in English between 1974 and 2020 were retrieved. Conclusion The included studies confirmed the presence of MSCs in the healthy periodontal ligament and in CPLs. Several surface markers are used for the characterization of these cells which, although not specific, are effective in cell recognition. Mesenchymal stem cells participate in tissue repair, exerting anti- inflammatory, immunosuppressive and proangiogenic effects, and are therefore involved in the progression and attenuation of CPLs or even in the persistence of these lesions.
Databáze: OpenAIRE
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