Targeting Peroxisome Proliferator-Activated Receptor-β/δ (PPARβ/δ) for the Treatment or Prevention of Alcoholic Liver Disease
| Autor: | Takayuki Koga, Jeffrey M. Peters |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Alcoholic liver disease Cirrhosis Pharmaceutical Science Peroxisome proliferator-activated receptor medicine.disease_cause chemistry.chemical_compound Insulin resistance Internal medicine medicine Animals Humans Liver Diseases Alcoholic PPAR-beta Pharmacology chemistry.chemical_classification Fatty acid metabolism business.industry food and beverages General Medicine medicine.disease PPAR gamma Endocrinology Liver chemistry Steatosis Liver cancer business Oxidative stress |
| Zdroj: | Biological and Pharmaceutical Bulletin. 44:1598-1606 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.b21-00486 |
| Popis: | Excessive, chronic alcohol consumption can lead to alcoholic liver disease. The etiology of alcoholic liver disease is multifactorial and is influenced by alterations in gene expression and changes in fatty acid metabolism, oxidative stress, and insulin resistance. These events can lead to steatosis, fibrosis, and eventually to cirrhosis and liver cancer. Many of these functions are regulated by peroxisome proliferator-activated receptors (PPARs). Thus, it is not surprising that PPARs can modulate the mechanisms that cause alcoholic liver disease. While the roles of PPARα and PPARγ are clearer, the role of PPARβ/δ in alcoholic liver disease requires further clarification. This review summarizes the current understanding based on recent studies that indicate that PPARβ/δ can likely be targeted for the treatment and/or the prevention of alcoholic liver disease. |
| Databáze: | OpenAIRE |
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