Phosphono-platelet activating factor I. synthesis of 1-O-hexadecyl-2-O-acetyl-glyceryl-3-(2-trimethyl ammonium-methyl) phosphonate and its platelet activating potency
| Autor: | Constantinos A. Demopoulos, Lena G. Kritikou, Michael C. Moschidis |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Blood Platelets
Serotonin Platelet-activating factor Chemistry Stereochemistry Organic Chemistry Phospholipid Total synthesis Cell Biology Biochemistry Phosphonate Phosphono-platelet activating factor Structure-Activity Relationship chemistry.chemical_compound Animals Potency lipids (amino acids peptides and proteins) Ammonium Platelet Rabbits Platelet Activating Factor Molecular Biology Phospholipids |
| Zdroj: | Chemistry and Physics of Lipids. 33:87-92 |
| ISSN: | 0009-3084 |
| Popis: | The total synthesis of 1-O-alkyl-2-acetyl-3-glyceryl-(2-trimethyl ammoniummethyl) phosphonate, the phosphono analogue of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, is described. The phosphonolipid shows much lower activity than the phospholipid stimulating serotonin release from rabbit platelets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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