Mechanisms by Which Kinesin-5 Motors Perform Their Multiple Intracellular Functions
| Autor: | Alina Goldstein-Levitin, Larisa Gheber, Himanshu Pandey, Mary Popov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Computer science
QH301-705.5 Intracellular Space Kinesins Motility Spindle Apparatus macromolecular substances Review Models Biological Catalysis Inorganic Chemistry Motor protein microtubules Microtubule kinesin-5 Animals Humans Physical and Theoretical Chemistry Biology (General) Molecular Biology Mitosis QD1-999 Spectroscopy mitosis Organic Chemistry General Medicine Computer Science Applications Chemistry Kinesin cell-cycle regulation of kinesin activity Protein Processing Post-Translational Neuroscience Intracellular |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 6420, p 6420 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Bipolar kinesin-5 motor proteins perform multiple intracellular functions, mainly during mitotic cell division. Their specialized structural characteristics enable these motors to perform their essential functions by crosslinking and sliding apart antiparallel microtubules (MTs). In this review, we discuss the specialized structural features of kinesin-5 motors, and the mechanisms by which these features relate to kinesin-5 functions and motile properties. In addition, we discuss the multiple roles of the kinesin-5 motors in dividing as well as in non-dividing cells, and examine their roles in pathogenetic conditions. We describe the recently discovered bidirectional motility in fungi kinesin-5 motors, and discuss its possible physiological relevance. Finally, we also focus on the multiple mechanisms of regulation of these unique motor proteins. |
| Databáze: | OpenAIRE |
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