Hemophilia Liver Transplantation Observational Study

Autor: Michael T. Wong, Bijan Eghtesad, Kenneth E. Sherman, Emily A. Blumberg, Peter G. Stock, Margaret V. Ragni, Valentina Stosor, Burc Barin, Donald Stablein, John J. Fung, Abhinav Humar, Nicholas N. Nissen
Rok vydání: 2016
Předmět:
Adult
CD4-Positive T-Lymphocytes
Male
medicine.medical_specialty
Time Factors
medicine.medical_treatment
Hepatitis C virus
HIV Infections
030204 cardiovascular system & hematology
Liver transplantation
medicine.disease_cause
Hemophilia A
Gastroenterology
03 medical and health sciences
Liver disease
0302 clinical medicine
Postoperative Complications
Internal medicine
medicine
Odds Ratio
Humans
Registries
Retrospective Studies
Transplantation
Univariate analysis
Hepatology
business.industry
Coinfection
Hazard ratio
virus diseases
Odds ratio
Hepatitis C
Chronic
Middle Aged
medicine.disease
United States
Liver Transplantation
Treatment Outcome
Anti-Retroviral Agents
Data Interpretation
Statistical
Multivariate Analysis
Disease Progression
030211 gastroenterology & hepatology
Surgery
Female
business
Liver Failure
Zdroj: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 23(6)
ISSN: 1527-6473
Popis: Hepatitis C virus (HCV) infection is the leading cause of liver disease in hemophilia patients. In those with human immunodeficiency virus (HIV)/HCV coinfection, the rate of liver disease progression is greater than in HCV monoinfected individuals. Despite antiretroviral therapy, which slows HCV liver disease progression, some require transplantation. Whether transplant outcomes are worse in hemophilic (H) rather than nonhemophilic (NH) candidates is unknown. In order to determine rates and predictors of pretransplant and posttransplant survival, we conducted a retrospective observational study using United Network for Organ Sharing national transplant registry data, comparing HCV+ H and NH candidates. We identified 2502 HCV+ liver transplant candidates from 8 US university-based transplant centers, between January 1, 2004 to December 31, 2010, including 144 HIV+ (6%) and 2358 HIV–; 36 H (1%) and 2466 NH; 1213 (48%) transplanted and 1289 not transplanted. Other than male predominance and younger age, each were P
Databáze: OpenAIRE
Externí odkaz: