No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood
| Autor: | Hollanders, Jonneke J., Israëls, Joël, Van Der Pal, Sylvia M., Verkerk, Paul H., Rotteveel, Joost, Finken, Martijn J J, Hille, E. T M, De Groot, C. H., Kloosterboer-Boerrigter, H., Den Ouden, A. L., Rijpstra, A., Verloove-Vanhorick, S. P., Vogelaar, J. A., Kok, J. H., Ilsen, A., Van Der Lans, M., Boelen-Van Der Loo, W. J C, Lundqvist, T., Heymans, H. S A, Duiverman, E. J., Geven, W. B., Duiverman, M. L., Geven, L. I., Vrijlandt, E. J L E, Mulder, A. L M, Gerver, A., Kollée, L. A A, Reijmers, L., Sonnemans, R., Wit, J. M., Dekker, F. W., Finken, M. J J, Weisglas-Kuperus, N., Keijzer-Veen, M. G., Van Der Heijden, A. J., Van Goudoever, J. B., Van Weissenbruch, M. M., Cranendonk, A., Delemarre-Van De Waal, H. A., De Groot, L., Samsom, J. F., De Vries, L. S., Rademaker, K. J., Moerman, E., Voogsgeerd, M., De Kleine, M. J K, Andriessen, P., Dielissen-Van Helvoirt, C. C M, Mohamed, I., Van Straaten, H. L M, Baerts, W., Veneklaas Slots-Kloosterboer, G. W., Tuller-Pikkemaat, E. M J, Ens-Dokkum, M. H., Van Steenbrugge, G. J. |
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| Přispěvatelé: | Neonatology, Other Research, Paediatrics, General Paediatrics, Paediatric Pulmonology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Reproduction & Development (AR&D), Pediatric surgery, ICaR - Circulation and metabolism |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Developmental Disabilities Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) Neuropsychological Tests Research Support Biochemistry medical Cohort Studies Young Adult Endocrinology Internal medicine Congenital Hypothyroidism medicine Journal Article Humans Young adult Non-U.S. Gov't Intelligence Tests Biochemistry medical Intelligence quotient business.industry Research Support Non-U.S. Gov't Biochemistry (medical) Infant Newborn Infant Low Birth Weight medicine.disease Congenital hypothyroidism Diabetes and Metabolism Thyroxine Low birth weight Premature birth Infant Extremely Premature Infant Small for Gestational Age Cohort Female Nervous System Diseases medicine.symptom business Infant Premature Psychomotor Performance Follow-Up Studies Cohort study |
| Zdroj: | Hollanders, J J, Israëls, J, van der Pal, S M, Verkerk, P H, Rotteveel, J & Finken, M J J 2015, ' No Association Between Transient Hypothyroxinemia of Prematurity and Neurodevelopmental Outcome in Young Adulthood ', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 12, pp. 4648-4653 . https://doi.org/10.1210/jc.2015-3078 Journal of Clinical Endocrinology and Metabolism, 100(12), 4648. The Endocrine Society Journal of clinical endocrinology and metabolism, 100(12), 4648-4653. The Endocrine Society Journal of Clinical Endocrinology and Metabolism, 100(12), 4648-4653. The Endocrine Society |
| ISSN: | 0021-972X |
| Popis: | Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective: The objective was to examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at a young adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,32 wk) and/or with a very low birth weight (ie, 1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoP was defined as a total T4 concentration< -3 SD of the daily mean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen’s examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, 1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found. |
| Databáze: | OpenAIRE |
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