Rationale for the design of an oncology trial using a generic targeted therapy multi-drug regimen for NSCLC patients without treatment options (Review)
| Autor: | Stefan Langhammer |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Antineoplastic Agents HIV Infections Disease Drug resistance Targeted therapy Carcinoma Non-Small-Cell Lung Internal medicine multi-drug regimen Drug Resistance Viral medicine Humans Molecular Targeted Therapy Drug regimen Immune Evasion Clinical Trials as Topic drug resistance business.industry targeted therapy drugs HIV Cancer Treatment options Articles General Medicine highly active antiretroviral therapy medicine.disease Regimen Drug Resistance Neoplasm Drug Design Tumor Escape Non small cell business |
| Zdroj: | Oncology Reports |
| ISSN: | 1791-2431 1021-335X |
| DOI: | 10.3892/or.2013.2631 |
| Popis: | Despite more than 70 years of research concerning medication for cancer treatment, the disease still remains one of the leading causes of mortality worldwide. Many cancer types lead to death within a period of months to years. The original class of chemotherapeutics is not selective for tumor cells and often has limited efficacy, while treated patients suffer from adverse side‑effects. To date, the concept of tumor‑specific targeted therapy drugs has not fulfilled its expectation to provide a key for a cure. Today, many oncology trials are designed using a combination of chemotherapeutics with targeted therapy drugs. However, these approaches have limited outcomes in most cancer indications. This perspective review provides a rationale to combine targeted therapy drugs for cancer treatment based on observations of evolutionary principles of tumor development and HIV infections. In both diseases, the mechanisms of immune evasion and drug resistance can be compared to some extent. However, only for HIV is a breakthrough treatment available, which is the highly active antiretroviral therapy (HAART). The principles of HAART and recent findings from cancer research were employed to construct a hypothetical model for cancer treatment with a multi‑drug regimen of targeted therapy drugs. As an example of this hypothesis, it is proposed to combine already marketed targeted therapy drugs against VEGFRs, EGFR, CXCR4 and COX2 in an oncology trial for non‑small cell lung cancer patients without further treatment options. |
| Databáze: | OpenAIRE |
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