Serum osteopontin: a biomarker of disease activity and predictor of relapsing course in patients with giant cell arteritis. Potential clinical usefulness in tocilizumab-treated patients
| Autor: | Giuseppe Murgia, Nekane Terrades-García, Maria C. Cid, Itziar Tavera-Bahillo, Georgina Espígol-Frigolé, Marco A. Alba, Javier Marco-Hernández, Chie Miyabe, Marc Corbera-Bellalta, Ester Planas-Rigol, Sergio Prieto-González, Ariel Ponce, Ana García-Martínez, José Hernández-Rodríguez, Sebastian Unizony |
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| Rok vydání: | 2017 |
| Předmět: |
Vasculitis
medicine.medical_specialty Immunology Gastroenterology corticosteroids 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tocilizumab Rheumatology Internal medicine medicine Immunology and Allergy 030212 general & internal medicine Osteopontin Interleukin 6 030203 arthritis & rheumatology biology business.industry giant cell arteritis C-reactive protein medicine.disease cytokines Giant cell arteritis chemistry biology.protein Biomarker (medicine) systemic vasculitis business Glucocorticoid Systemic vasculitis medicine.drug |
| Zdroj: | RMD Open |
| ISSN: | 2056-5933 |
| Popis: | Background Osteopontin (OPN) is a glycoprotein involved in Th1 and Th17 differentiation, tissue inflammation and remodelling. We explored the role of serum OPN (sOPN) as a biomarker in patients with giant cell arteritis (GCA). Methods sOPN was measured by immunoassay in 76 treatment-naïve patients with GCA and 25 age-matched and sex-matched controls. In 36 patients, a second measurement was performed after 1 year of glucocorticoid treatment. Baseline clinical and laboratory findings, as well as relapses and glucocorticoid requirements during follow-up, were prospectively recorded. sOPN and C reactive protein (CRP) were measured in 32 additional patients in remission treated with glucocorticoids or tocilizumab (interleukin 6 (IL-6) receptor antagonist). In cultured temporal arteries exposed and unexposed to tocilizumab, OPN mRNA expression and protein production were measured by reverse transcription polymerase chain reaction (RT-PCR) and immunoassay, respectively. Results sOPN concentration (ng/mL; mean±SD) was significantly elevated in patients with active disease (116.75±65.61) compared with controls (41.10±22.65; p |
| Databáze: | OpenAIRE |
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