Rhodium(III)‐Catalyzed Atroposelective Synthesis of Biaryls by C−H Activation and Intermolecular Coupling with Sterically Hindered Alkynes
| Autor: | Xingwei Li, Xiaolin Zhu, Zisong Qi, Guangfan Zheng, Ruijie Mi, Shuailei Zhai, Xiaoming He, Zhiyan Huang, Yuxia Zhao, Fen Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Steric effects
chemistry.chemical_classification Annulation 010405 organic chemistry Regioselectivity chemistry.chemical_element Alkyne General Medicine General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences Rhodium chemistry.chemical_compound chemistry Axial chirality Amide |
| Zdroj: | Angewandte Chemie International Edition. 59:13288-13294 |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | Reported herein is the atroposelective synthesis of biaryl NH isoquinolones by RhIII -catalyzed C-H activation of benzamides and intermolecular [4+2] annulation for a broad scope of 2-substituted 1-alkynylnaphthalenes, as well as sterically hindered, symmetric diarylacetylenes. The axial chirality is constructed based on dynamic kinetic transformation of the alkyne in redox-neutral annulation with benzamides, with alkyne insertion being stereodetermining. The reaction accommodates both benzamides and heteroaryl carboxamides and proceeds in excellent regioselectivity (if applicable) and enantioselectivities (average 91.8 % ee). An enantiomerically and diastereomerically pure rhodacyclic complex was prepared and offers insight into enantiomeric control of the coupling system, wherein the steric interactions between the amide directing group and the alkyne substrate dictate both the regio- and enantioselectivity. |
| Databáze: | OpenAIRE |
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