Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes
| Autor: | M. Angeles Argudín, Claire Nonhoff, Magali Dodémont, L. Nienhaus, Sandrine Roisin, Olivier Denis, Ariane Deplano, R. De Mendonça |
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| Rok vydání: | 2018 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
0301 basic medicine medicine.drug_class 030106 microbiology Cephalosporin Antibiotics Microbial Sensitivity Tests Drug resistance Biology medicine.disease_cause beta-Lactam Resistance beta-Lactamases Epidemiology and Surveillance Microbiology Cefoxitin 03 medical and health sciences Bacterial Proteins medicine Humans Penicillin-Binding Proteins Missense mutation Pharmacology (medical) Overproduction Gene Oxacillin Retrospective Studies Pharmacology biochemical phenomena metabolism and nutrition Staphylococcal Infections Anti-Bacterial Agents Infectious Diseases Staphylococcus aureus medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 62 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.00091-18 |
| Popis: | Methicillin-resistant Staphylococcus aureus isolates lacking mec genes ( n = 32), collected from Belgian hospitals, were characterized for their β-lactamase production and the presence of mutations in pbp genes, the pbp4 promoter, and genes involved in penicillin-binding protein 4 overproduction ( gdpP and yjbH ). Twelve isolates were β-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations in pbp genes. A few isolates also showed mutations in the pbp4 promoter. |
| Databáze: | OpenAIRE |
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