Perfluorodecanoic acid, a peroxisome proliferator, activates phospholipase C, inhibits CTP:phosphocholine cytidylyltransferase, and elevates diacylglycerol in rat liver
| Autor: | Latha Narayanan, Nicholas V. Reo, Mehdi Adinehzadeh, Katrina B. Kling |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Cytidylyltransferase Toxicology Microbodies Diglycerides Choline-phosphate cytidylyltransferase Eating chemistry.chemical_compound Cytosol Microsomes Internal medicine medicine Animals Diglyceride Phosphocholine Diacylglycerol kinase Analysis of Variance Fluorocarbons Phospholipase C General Medicine Nucleotidyltransferases Rats Inbred F344 Rats Endocrinology Liver chemistry Biochemistry Type C Phospholipases Phosphatidylcholines Microsome lipids (amino acids peptides and proteins) Decanoic Acids |
| Zdroj: | Toxicology Letters. 86:1-11 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/0378-4274(96)03653-3 |
| Popis: | Perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) are peroxisome proliferators that cause hepatotoxicity in rodents. This study shows that PFDA activates liver phospholipase C (PLC) and inhibits CTP:phosphocholine cytidylyltransferase (CT). PLC cytosolic and microsomal activities were increased 1.4- and 1.7-fold, respectively. CT activities were decreased to 58% (cytosol) and 36% (microsome) of control values. PFDA also caused a threefold increase in liver diacylglycerol (DAG) concentration. PFOA had no effect on the enzyme activities or DAG concentration. Together with previous results, these data suggest that PFDA activates a phosphatidylcholine-specific PLC causing an increase in liver phosphocholine and DAG. These effects are discussed in relation to cellular signalling processes that may provide a mechanism for PFDA-induced hepatotoxicity. |
| Databáze: | OpenAIRE |
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