The frequency dependence of osmo-adaptation in Saccharomyces cerevisiae
| Autor: | Dale Muzzey, Alexander van Oudenaarden, Carlos A. Gomez-Uribe, Jerome T. Mettetal |
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| Rok vydání: | 2008 |
| Předmět: |
Glycerol
Saccharomyces cerevisiae Proteins Osmotic shock Systems biology Saccharomyces cerevisiae Gene regulatory network Models Biological Article Osmotic Pressure Negative feedback Gene Expression Regulation Fungal Gene expression Osmotic pressure Gene Regulatory Networks Phosphorylation Genetics Cell Nucleus Feedback Physiological Multidisciplinary biology Systems Biology Osmolar Concentration biology.organism_classification Adaptation Physiological Biophysics Signal transduction Mitogen-Activated Protein Kinases Signal Transduction |
| Zdroj: | Science (New York, N.Y.). 319(5862) |
| ISSN: | 1095-9203 |
| Popis: | The propagation of information through signaling cascades spans a wide range of time scales, including the rapid ligand-receptor interaction and the much slower response of downstream gene expression. To determine which dynamic range dominates a response, we used periodic stimuli to measure the frequency dependence of signal transduction in the osmo-adaptation pathway of Saccharomyces cerevisiae . We applied system identification methods to infer a concise predictive model. We found that the dynamics of the osmo-adaptation response are dominated by a fast-acting negative feedback through the kinase Hog1 that does not require protein synthesis. After large osmotic shocks, an additional, much slower, negative feedback through gene expression allows cells to respond faster to future stimuli. |
| Databáze: | OpenAIRE |
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