Expression and function of cyclooxygenase-2 in mesothelial cells during late phase of rat carrageenin-induced pleurisy
| Autor: | Michiko Ogino, Sumitaka Matsuo, Yoshiteru Harada, Keiko Ogino, Maki Saito, Michiko Kawamura, Ko Hatanaka |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Pathology medicine.medical_specialty Carrageenan medicine.disease_cause Epithelium General Biochemistry Genetics and Molecular Biology Rats Sprague-Dawley Extracellular matrix medicine Animals General Pharmacology Toxicology and Pharmaceutics Pleurisy biology Chemistry General Medicine Hyperplasia medicine.disease Epoprostenol Molecular biology Rats Isoenzymes medicine.anatomical_structure Cyclooxygenase 2 Prostaglandin-Endoperoxide Synthases biology.protein Cyclooxygenase Irritation Mesothelial Cell Nimesulide medicine.drug |
| Zdroj: | Life Sciences. 65:PL161-PL166 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/s0024-3205(99)00384-7 |
| Popis: | We have previously shown that the inducible isoform of the cyclooxygenases, COX-2, is strongly expressed in pleural exudate leukocytes early (between 3 and 7 hr after irritation) during rat carrageenin-induced pleurisy. The present study further examined COX-2 expression and disclosed that mesothelial cells expressed COX-2 later (12 to 24 hr after irritation) in this model. A COX-2 inhibitor, nimesulide, lowered the intrapleural level of 6-keto-PGF1alpha and inhibited hyperplasia of the pleural matrix, suggesting that COX-2 expressed in mesothelial cells may play a role in the synthesis of extracellular matrix through formation of PGI2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect