3-(2-Carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex

Autor:	Ian A. McDonald, K. T. Stewart, Harrison Boyd L, Bruce M. Baron, Salituro Francesco G, Philip L. Nyce
Rok vydání:	1990
Předmět:	Receptor complex Indoles N-Methylaspartate Stereochemistry Glycine Binding Competitive Hippocampus Receptors N-Methyl-D-Aspartate Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Animals Glycine receptor Cerebral Cortex chemistry.chemical_classification D aspartate Binding Sites Molecular Structure Bicyclic molecule Chemistry Antagonist Biological activity Strychnine Rats Dicarboxylic acid Molecular Medicine Propionates
Zdroj:	Journal of Medicinal Chemistry. 33:2944-2946
ISSN:	1520-4804 0022-2623
DOI:	10.1021/jm00173a003
Popis:	L'acide 3-(4,6-dichloro-2-carboxyindol-3-yl) propionique ainsi que d'autres derives de l'acide indolepropionique representent une nouvelle classe d'antagonistes de l'acide N-methyl-D-aspartique, agissant au niveau d'un site de liaison de la glycine insensible a la strychnine
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385ade94be99a1a57a57eb622859c1f4 https://doi.org/10.1021/jm00173a003 Zobrazit plný text záznamu