Differentiation of Abnormal Blood Flow Patterns in Coronary Arteries Based on Doppler Catheter Recordings
| Autor: | Victor K. Hargrave, Thomas A. Ports, James P. Srebro, Lawrence Talbot, Paul G. Yock, Scott J. Denardo |
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| Rok vydání: | 1991 |
| Předmět: |
Cardiac Catheterization
medicine.medical_specialty medicine.medical_treatment Hemodynamics Coronary Artery Disease 030204 cardiovascular system & hematology 03 medical and health sciences symbols.namesake 0302 clinical medicine Coronary Circulation Humans Medicine Ultrasonics 030212 general & internal medicine Ultrasonography Cardiac catheterization Fourier Analysis business.industry Coronary Thrombosis Lasers Reynolds number Laminar flow Blood flow Coronary Vessels Coronary arteries medicine.anatomical_structure Flow (mathematics) symbols Radiology Cardiology and Cardiovascular Medicine business Doppler effect Blood Flow Velocity Biomedical engineering |
| Zdroj: | Angiology. 42:711-725 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/000331979104200905 |
| Popis: | Abnormal arterial blood flow patterns have been implicated as etiologic factors in thrombosis and atherosclerosis. Intravascular pulsed Doppler ultrasound techniques with fast-Fourier transform analysis offer the opportunity to measure these abnormalities. The authors hypothesized that statistical analysis of radial-directed beam spectra could be used to distinguish disturbed from nondisturbed flow and that analysis of conventional axial-directed beam spectra could then be used to distinguish laminar high-shear from laminar low-shear flow. They developed a scaled-up in-vitro model of coronary flow consisting of a glycerol/H 2O test fluid flowing through an acrylic cylinder at Reynolds numbers spanning the typical physiologic range within the coronary arteries. A scaled-up Doppler catheter with the capacity for 90° reflection of the beam was placed centrally. Disturbed flow was created by introducing a flow screen, and altered shear rates were produced by changing the Reynolds number. For the radial-directed beam studies, the coefficients of variation of the Doppler spectra for the disturbed flow states were significantly greater than for the nondisturbed flow states (p < 0.01). For the axial-directed beam studies, the coefficients of variation of the Doppler spectra for the laminar high-shear flow states were significantly greater than for the laminar low-shear flow states (p < 0.01). They conclude that abnormal blood flow patterns can be differentiated by the selective use of radial-directed and axial-directed Doppler catheter recordings. |
| Databáze: | OpenAIRE |
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