The predictive value of pre- and post-induction chemotherapy plasma EBV DNA level and tumor volume for the radiosensitivity of locally advanced nasopharyngeal carcinoma
| Autor: | Song, Yang, Xiao, He, Yang, Zhenzhou, Geng, Mingying, Ma, Jungang, Ren, Yujiang, Liu, Yun, Wang, Ge |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Intensity-modulated radiation therapy Radiosensitivity Logistic regression 03 medical and health sciences 030104 developmental biology 0302 clinical medicine radiosensitivity hemic and lymphatic diseases 030220 oncology & carcinogenesis Induction chemotherapy Nasopharyngeal carcinoma Epstein-Barr virus Original Article |
| Zdroj: | EXCLI Journal |
| Popis: | This study was dedicated to investigate the predictive value of pre- and post-induction chemotherapy plasma EBV (Epstein-Barr Virus) DNA level and tumor volume for the radiosensitivity of locally advanced NPC. 129 previously untreated locally advanced NPC patients were enrolled. Plasma EBV-DNA copy number and tumor volume was detected before and after induction chemotherapy. The tumor volume was also measured after radiotherapy. Among 129 patients, 98 were positive for EBV DNA. The residual gross target volume of the primary tumor (GTVnx) and GTVnd after radiotherapy was positively correlated with post-induction chemotherapy EBV copy number (rho=0.357, P EXCLI Journal;Vol. 16 2017 |
| Databáze: | OpenAIRE |
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