Protective effect of honokiol against LPS-induced lung injury via attenuation of matrix metalloproteinase-9 and oxidative stress
| Autor: | Zheng-Tao Gu, Xuan He, Hong-Bo Li, Lin Wang, Lei Su |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Honokiol Lung injury Pharmacology medicine.disease_cause General Biochemistry Genetics and Molecular Biology honokiol Superoxide dismutase Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine oxidative stress lcsh:QH301-705.5 medicine.diagnostic_test biology Glutathione respiratory tract diseases 030104 developmental biology Bronchoalveolar lavage chemistry acute lung injury lcsh:Biology (General) inflammation 030220 oncology & carcinogenesis Myeloperoxidase biology.protein General Agricultural and Biological Sciences MMP-9 Oxidative stress |
| Zdroj: | Archives of Biological Sciences, Vol 68, Iss 4, Pp 877-881 (2016) |
| ISSN: | 1821-4339 0354-4664 |
| Popis: | Despite high morbidity and mortality, no effective options are available for the treatment of acute lung injury (ALI). Therefore, the present study investigated the protective effect of honokiol (HK) on ALI via determination of its effect on several key biomarkers. The results of the study showed that HK significantly inhibited the infiltration of neutrophils and protein leakage induced by lipopolysaccharide (LPS) (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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