Nerve growth factor: a survey of activity on immune and hematopoietic cells
| Autor: | Luigi Aloe, Stefano De Santis, Eliana Vigneti, Sergio Amadori, Maria Domenica Simone, Giuseppe Papa |
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| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
Stromal cell medicine.medical_treatment Bone Marrow Cells Receptors Nerve Growth Factor Biology Bone marrow Hematopoietic stem cells Leukemia Lymphocytes NGF Immune system medicine Animals Humans Nerve Growth Factors Progenitor cell Inflammation Growth factor Hematology General Medicine Hematopoietic Stem Cells medicine.disease Hematologic Diseases Lymphoproliferative Disorders medicine.anatomical_structure Nerve growth factor Immune System Diseases nervous system Oncology Immunology Stem cell Settore MED/15 - Malattie del Sangue |
| Zdroj: | Hematological Oncology. 17:1-10 |
| ISSN: | 1099-1069 0278-0232 |
| DOI: | 10.1002/(sici)1099-1069(199903)17:1<1::aid-hon635>3.0.co;2-l |
| Popis: | Nerve growth factor (NGF) is a well characterized molecule required for the survival and differentiation of a variety of cell types both in the peripheral and central nervous system. Numerous studies published in recent years have demonstrated that NGF affects different functional activities of mature immune and hematopoietic cells. Other studies have revealed that hematopoietic progenitor cells from bone marrow, umbilical cord blood and peripheral blood are receptive to the action of NGF and that bone marrow stromal cells produce/respond to NGF during different steps of normal hematopoiesis. Elevated levels of NGF have been found in a number of inflammatory diseases, including those of autoimmune nature and in myeloproliferative pathologies. This review presents these data and discusses the hypothesis of a possible functional role of NGF in immune and hematopoietic disorders. |
| Databáze: | OpenAIRE |
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