Peridialytic serum cytokine levels and their relationship with postdialysis fatigue and recovery in patients on chronic haemodialysis - A preliminary study

Autor: Anna Picca, Bert Lenaert, Enrico Di Stasio, Astrid D.H. Brys, Riccardo Calvani, Giovanni Gambaro, Maurizio Bossola, Emanuele Marzetti
Přispěvatelé: Section Neuropsychology, RS: FPN NPPP I, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
SYMPTOMS
medicine.medical_treatment
Biochemistry
Gastroenterology
VARIABLES
0302 clinical medicine
MARKERS
DIALYSIS
Immunology and Allergy
Medicine
Depression (differential diagnoses)
Fatigue
Aged
80 and over
Hematology
MULTIPLE-SCLEROSIS
ASSOCIATION
Middle Aged
DEPRESSION
Cytokine
030220 oncology & carcinogenesis
Cytokines
Female
medicine.symptom
Adult
medicine.medical_specialty
Immunology
Inflammation
TIRD
PDF
Proinflammatory cytokine
MECHANISMS
03 medical and health sciences
Young Adult
Immune system
INFLAMMATION
Renal Dialysis
Internal medicine
Humans
Molecular Biology
Dialysis
Aged
business.industry
Multiple sclerosis
fungi
Settore MED/09 - MEDICINA INTERNA
Postdialysis
medicine.disease
SICKNESS
030104 developmental biology
nervous system
Etiology
Kidney Failure
Chronic
business
Zdroj: Cytokine, 135:155223. Elsevier Science
ISSN: 1096-0023
1043-4666
Popis: Background: The aetiology of postdialysis fatigue (PDF), an intermittent but debilitating fatigue occurring after haemodialysis (HD) treatment, is still unclear. In other inflammatory diseases, increasing evidence points toward the involvement of the immune system in the onset of fatigue symptoms. Altered serum levels of inflammatory cytokines have also been shown in HD patients. Therefore, we investigated whether pre- and postdialysis serum levels of pro- and anti-inflammatory cytokines (i.e. IL-1β, IL-6, TNF-α and IL-10) or their intradialytic changes (if any) were related to PDF or the time HD patients reported needing to recover from HD treatment (TIRD). Methods: Serum levels of IL-1β, IL-6, TNF-α and IL-10 were measured immediately before and after HD in 45 patients using commercially available kits on an ELLA™ automated immunoassay system. The presence and severity of PDF as well as TIRD duration were assessed by self-report measures. Key results: Seventy-four percent of patients reported PDF, with a median PDF severity index of 3.30 [IQR: 3.00–4.30] on a scale from 1 to 5. Median TIRD was 120 min [IQR: 60–480]. PDF severity correlated strongly with TIRD, rs = 0.85, p < 0.001. Only predialysis levels of IL-10 significantly and positively correlated with PDF severity (rs = 0.43, p = 0.003). Conclusion: Findings of the present study do not support the involvement of the immune system in the onset of PDF or the time patients needed to recover from HD treatment. A positive, but counterintuitive relationship was found between predialysis levels of anti-inflammatory IL-10 and PDF severity, which warrants further research.
Databáze: OpenAIRE
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