Zmiany w aktywności podstawowych parametrów biochemicznych wskazujących na nadmierne spożycie alkoholu
| Autor: | Anna Sito, Michał Piotrowicz, Peter Liedke, Ewa Ochwanowska, Bożena Witek, Teresa Tymińska-Tkacz, Agnieszka Prokop |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Bilirubin nadużywanie alkoholu media_common.quotation_subject Alcohol abuse Alcohol chemistry.chemical_compound biowskaźniki Internal medicine medicine In patient lcsh:Social sciences (General) media_common lcsh:R5-920 Ethanol business.industry Alcohol dependence Abstinence medicine.disease zespół uzależnienia od alkoholu Psychiatry and Mental health chemistry Biochemistry Alcohol dependence syndrome lcsh:H1-99 Liver function business lcsh:Medicine (General) Biomarkers |
| Zdroj: | Alcoholism and Drug Addiction, Vol 28, Iss 4, Pp 235-250 (2015) |
| ISSN: | 0867-4361 |
| Popis: | Introduction Health-harming alcohol drinking leads to metabolic changes and, consequently, to an emergence of chemical compounds in the blood that can be considered as biological indicators of alcohol intake. These markers indicate both acute and chronic ethanol consumption. The aim of the present study was to determine the changes in the activity of the basic biochemical parameters indicative of alcohol abuse on admission and after 5-week hospitalisation assigned to subgroups by age and clinical variables. Material and methods The examined group was composed of 60 alcohol-dependent males aged 20–66 undergoing 5-week inpatient treatment. A number of socio-demographic and clinical interviews were carried out with the patients and blood samples were taken for laboratory tests. The following markers were assessed twice (on admission to the unit and after 5 weeks of hospitalisation): MCV, activity of AST, ALT and GGT, level of bilirubin, blood glucose and the ratio of the number of platelets (PLT). Results The activity of AST, ALT, GGT was significantly higher in patients studied at the time of admission to hospital. The values of these indices in patients with alcoholism after 5 weeks of abstinence improved significantly. Discussion The metabolic processes of alcohol-dependent subjects are very complex. We could look for variables such as age, length and intensity of alcohol dependence, quantity and type of alcohol doses or liver function. Conclusion Five-week hospitalisation is an important factor affecting an improvement in biochemical parameter values among alcohol-dependent persons. |
| Databáze: | OpenAIRE |
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