Recent Advances in the Medicinal Chemistry of Novel Erythromycin- Derivatized Antibiotics
| Autor: | Datong Tang, Lu Ying |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Ketolides
medicine.drug_class Chemistry Pharmaceutical Antibiotics Telithromycin Erythromycin Drug Resistance Microbial General Medicine Drug resistance Azithromycin Medicinal chemistry Anti-Bacterial Agents Macrolide Antibiotics Antibiotic resistance Clarithromycin Drug Discovery medicine Humans Macrolides medicine.drug |
| Zdroj: | Current Topics in Medicinal Chemistry. 10:1441-1469 |
| ISSN: | 1568-0266 |
| DOI: | 10.2174/156802610792232042 |
| Popis: | Development of novel erythromycin-based antibiotics has been one of the most studied topics in the past three decades. Such tremendous efforts have generated a number of beneficiary drugs such as clarithromycin, azithromycin and telithromycin. However, widespread application of antibiotics in clinical practice has triggered an increasing emergence of bacterial resistance. Therefore, discovery of novel macrolide antibiotics to suppress the resistance is urgent for human healthcare. This review focuses on advances in the area since 2004. |
| Databáze: | OpenAIRE |
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