Interleukin-18 and Hematopoietic Recovery after Allogeneic Stem Cell Transplantation
| Autor: | Thomas Luft, Dietrich W. Beelen, Carsten Müller-Tidow, Peter Dreger, Lambros Kordelas, Aleksandar Radujkovic, Rashit Bogdanov |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Medizin lcsh:RC254-282 Article interleukin-18 03 medical and health sciences non-relapse mortality 0302 clinical medicine allogeneic stem cell transplantation Internal medicine medicine Progenitor cell business.industry Hazard ratio Odds ratio lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens hematopoietic recovery Transplantation Haematopoiesis 030104 developmental biology 030220 oncology & carcinogenesis Cohort Interleukin 18 Stem cell business |
| Zdroj: | Cancers, Vol 12, Iss 2789, p 2789 (2020) Cancers Volume 12 Issue 10 |
| Popis: | Interleukin-18 (IL-18) is an immunoregulatory cytokine and a context-dependent regulator of hematopoietic stem/progenitor cell (HSPC) quiescence in murine models. In a previous study, high pre-conditioning levels of IL-18 were associated with increased non-relapse mortality (NRM) after allogeneic stem cell transplantation (alloSCT). To investigate the clinical impact of IL-18 status on hematopoietic function, the associations of pre-conditioning and day 0&ndash 3 cytokine levels with platelet and neutrophil recovery were analyzed in a training cohort of 714 allografted patients. In adjusted logistic regression analyses, both increasing pre-conditioning and day 0&ndash 3 IL-18 levels had a significantly higher adjusted odds ratio (aOR) of delayed platelet and neutrophil recovery on day +28 post-transplant (aOR per two-fold increase: 1.6&ndash 2.0). The adverse impact of high pre-conditioning IL-18 on day +28 platelet recovery was verified in an independent cohort of 673 allografted patients (aOR per two-fold increase: 1.8 and 1.7 for total and free IL-18, respectively). In both cohorts, a platelet count &le 20/nL on day +28 was associated with a significantly increased hazard of NRM (hazard ratio 2.13 and 2.94, respectively). Our findings support the hypothesis that elevated peritransplant IL-18 levels affect post-transplant HSPC function and may provide a rationale to explore modulation of IL-18 for improving alloSCT outcomes. |
| Databáze: | OpenAIRE |
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