A Pooled Analysis to Compare the Clinical Characteristics of Human Papillomavirus–positive and -Negative Cervical Precancers
| Autor: | Eduardo L. Franco, Tom Wright, Richard Muwonge, Mariam El-Zein, Cynthia Firnhaber, Vanessa Van De Wyngard, Jack Cuzick, Jerome L. Belinson, Joseph Monsonego, Rachael Adcock, Salaheddin M. Mahmud, Long Fu Xi, Mahboobeh Safaeian, Mark Schiffman, Avril Swarts, Partha Basu, Sandra D. Isidean, John Lin, Jennifer S. Smith, Catterina Ferreccio, Amanda J. Pierz, Philip E. Castle, Shagufta Aslam, Patti E. Gravitt, Sam Ratnam |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Human Papillomavirus Positive Oncology Cancer Research medicine.medical_specialty Ovid medline MEDLINE Uterine Cervical Neoplasms Global Health 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic Cervical intraepithelial neoplasia grade 2 Internal medicine medicine Humans Papillomaviridae Early Detection of Cancer Cervical cancer business.industry Papillomavirus Infections virus diseases Cancer Prognosis Uterine Cervical Dysplasia medicine.disease female genital diseases and pregnancy complications 030104 developmental biology Pooled analysis 030220 oncology & carcinogenesis Female business Cancer risk Precancerous Conditions |
| Zdroj: | Cancer Prevention Research. 13:829-840 |
| ISSN: | 1940-6215 1940-6207 |
| Popis: | Given that high-risk human papillomavirus (HPV) is the necessary cause of virtually all cervical cancer, the clinical meaning of HPV-negative cervical precancer is unknown. We, therefore, conducted a literature search in Ovid MEDLINE, PubMed Central, and Google Scholar to identify English-language studies in which (i) HPV-negative and -positive, histologically confirmed cervical intraepithelial neoplasia grade 2 or more severe diagnoses (CIN2+) were detected and (ii) summarized statistics or deidentified individual data were available to summarize proportions of biomarkers indicating risk of cancer. Nineteen studies including 3,089 (91.0%) HPV-positive and 307 (9.0%) HPV-negative CIN2+ were analyzed. HPV-positive CIN2+ (vs. HPV-negative CIN2+) was more likely to test positive for biomarkers linked to cancer risk: a study diagnosis of CIN3+ (vs. CIN2; 18 studies; 0.56 vs. 0.24; P < 0.001) preceding high-grade squamous intraepithelial lesion cytology (15 studies; 0.54 vs. 0.10; P < 0.001); and high-grade colposcopic impression (13 studies; 0.30 vs. 0.18; P = 0.03). HPV-negative CIN2+ was more likely to test positive for low-risk HPV genotypes than HPV-positive CIN2+ (P < 0.001). HPV-negative CIN2+ appears to have lower cancer risk than HPV-positive CIN2+. Clinical studies of human high-risk HPV testing for screening to prevent cervical cancer may refer samples of HPV test–negative women for disease ascertainment to correct verification bias in the estimates of clinical performance. However, verification bias adjustment of the clinical performance of HPV testing may overcorrect/underestimate its clinical performance to detect truly precancerous abnormalities. |
| Databáze: | OpenAIRE |
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