Can intensity-modulated radiotherapy preserve oral health-related quality of life of nasopharyngeal carcinoma patients?
| Autor: | Victor Ho-Fun Lee, Sherry C.Y. Ng, Jonathan S. T. Sham, Edmond H.N. Pow, Dora L.W. Kwong |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Saliva Time Factors medicine.medical_treatment Oral Health Oral health Quality of life Internal medicine Surveys and Questionnaires medicine Humans Parotid Gland Radiology Nuclear Medicine and imaging Prospective Studies Aged Radiation Nasopharyngeal Carcinoma business.industry Carcinoma Cancer Nasopharyngeal Neoplasms Radiotherapy Dosage Recovery of Function Middle Aged medicine.disease Surgery Radiation therapy stomatognathic diseases Oncology Nasopharyngeal carcinoma Quality of Life Hong Kong Parotid saliva Female Intensity modulated radiotherapy Radiotherapy Intensity-Modulated business Salivation |
| Zdroj: | International journal of radiation oncology, biology, physics. 83(2) |
| ISSN: | 1879-355X |
| Popis: | Purpose To investigate the changes in salivary function and oral health-related quality of life for patients with nasopharyngeal carcinoma treated by intensity-modulated radiotherapy (IMRT). Methods and Materials A total of 57 patients with early-stage nasopharyngeal carcinoma received IMRT. The parotid and whole saliva flow was measured, and the Medical Outcomes Study 36-item short form, European Organization for Research and Treatment of Cancer Quality of Life questionnaire-C30, European Organization for Research and Treatment of Cancer Quality of Life questionnaire 35-item head-and-neck module, and Oral Health Impact Profile questionnaires were completed at baseline and 2, 6, 12, 18, and 24 months after IMRT. Results Parotid saliva flow recovered fully after 1 year and maintained. Whole saliva flow recovered partially to 40% of baseline. A general trend of deterioration in most quality of life scales was observed after IMRT, followed by gradual recovery. Persistent oral-related symptoms were found 2 years after treatment. Conclusion IMRT for early-stage nasopharyngeal carcinoma could only partially preserve the whole salivary function and oral health-related quality of life. |
| Databáze: | OpenAIRE |
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