Multicentric reticulohistiocytosis: case report with response to infliximab and review of treatment options
Autor: | Cristina Macía-Villa, Antonio Zea-Mendoza |
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Rok vydání: | 2014 |
Předmět: |
Male
medicine.medical_specialty Disease Life activity 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Rheumatology Internal medicine medicine Humans Treatment Failure Reticulohistiocytosis 030203 arthritis & rheumatology business.industry Treatment options Multicentric reticulohistiocytosis General Medicine Middle Aged medicine.disease Hand Dermatology Infliximab Surgery Antirheumatic Agents business Histiocytosis medicine.drug Medical literature |
Zdroj: | Clinical rheumatology. 35(2) |
ISSN: | 1434-9949 |
Popis: | Multicentric reticulohistiocytosis (MRH) is a rare systemic and devastating disease with main involvement of skin and joints, frequently related with malignancies. Macrophages and TNFα are the main targets of multiple treatment options with variable results. Although MRH has the tendency of self-resolve in an average of 8 years, treatment must be started early to avoid sequelae, mainly in joints with severe deformities and daily life activity impairment. We describe a 50-year-old man with skin and joint involvement, with a non-previously described muscle affectation, that failed to different drugs and achieved skin improvement with infliximab. We review for the first time in medical literature the available therapeutic options of MRH and its outcomes and propose possible future targets. |
Databáze: | OpenAIRE |
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