MicroRNA-101 has a suppressive role in osteosarcoma cells through the targeting of c-FOS
| Autor: | Song Wu, Rongzhen He, Hansong Xia, Zili Wang, Yu Wei |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research proliferation Cell Biology migration 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Downregulation and upregulation osteosarcoma microRNA medicine Gene knockdown Oncogene microRNA-101 Articles General Medicine Cell cycle invasion Molecular biology Retraction 030104 developmental biology medicine.anatomical_structure Apoptosis Cell culture 030220 oncology & carcinogenesis |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | MicroRNAs (miRs) have been implicated in the development and progression of osteosarcoma (OS). However, the underlying mechanism of miR-101 in regulating of the proliferation, migration and invasion of OS cells remains to be elucidated. In the present study, reverse transcription-quantitative polymerase chain reaction data revealed that miR-101 was frequently downregulated in the tissue samples of 12 patients with OS compared with their matched adjacent non-tumor tissues. Furthermore, miR-101 was significantly downregulated in three common OS cell lines, Saos-2, MG63 and U2OS, compared with the human osteoblast cell line, hFOB1.19 (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|