Splenic irradiation combined with tumor irradiation promotes T cell infiltration in the tumor microenvironment and helps in tumor control
| Autor: | Yongrui Bai, Jian-Xin Gao, Hua-Ying Xie, Xiao-xing Liu, Lin-Feng Li, Hai-yan Chen |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
T cell aggregation Receptors CXCR3 T-Lymphocytes medicine.medical_treatment Interleukin-1beta Biophysics Spleen CXCR3 Biochemistry Mice 03 medical and health sciences T-Cell Chemokine Lymphocytes Tumor-Infiltrating 0302 clinical medicine Immune system Cell Movement Neoplasms Tumor Microenvironment medicine Animals Molecular Biology Tumor microenvironment Chemistry Cancer Cell Biology medicine.disease Radiation therapy Disease Models Animal Treatment Outcome 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Chemokines |
| Zdroj: | Biochemical and Biophysical Research Communications. 510:156-162 |
| ISSN: | 0006-291X |
| Popis: | Locally applied radiation to the tumor is reported to stimulate systemic immune response. During radiotherapy to the abdominal cancer, spleen often receives certain dose, though as an important immune organ, little is known about the impact of splenic irradiation (SI) on systemic immune and local tumor control. Through a mice model, we found that the combination of SI with tumor irradiation (TI) helped in local control. The analysis of the tumor infiltrating leucocytes demonstrated that SI plus TI brought more T cell aggregation in the tumor microenvironment (TME), which helped in tumor control. Increased T cell infiltration may be partly due to higher expression of T cell chemokine in the TME and more expression of CXCR3 on the T cells in the spleen after SI. SI produced more IL-1β in the spleen, IL-1β stimulated the expression of CXCR3 on the T cells, and enhanced their migration ability. Taken together, radiation to the spleen combined with TI helped in local control through promoting T cell infiltration, and may be a considerable means to enhance the immunomodulatory of radiotherapy. |
| Databáze: | OpenAIRE |
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