The Impact of Selective Dopamine D2, D3 and D4 Ligands on the Rat Gambling Task
| Autor: | Isabelle Boileau, C. A. Winstanley, Abby Ramzi, Maram A. T. M. Khaled, Jessica Hatch, Abhiram Pushparaj, Bernard Le Foll, Talal Masood, Patricia Di Ciano, Aaron Kim |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Punishment (psychology) media_common.quotation_subject Decision Making Dopamine Agents lcsh:Medicine Biology Ligands Affect (psychology) Task (project management) Punishment Reward Dopamine Dopamine receptor D2 Reaction Time medicine Animals Rats Long-Evans lcsh:Science media_common Multidisciplinary Receptors Dopamine D2 Addiction lcsh:R Receptors Dopamine D4 Receptors Dopamine D3 Iowa gambling task Rats Dopamine D2 Receptor Antagonists Games Experimental Gambling Conditioning Operant Dopamine Antagonists Gambling disorder lcsh:Q psychological phenomena and processes Research Article medicine.drug Cognitive psychology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 9, p e0136267 (2015) |
| ISSN: | 1932-6203 |
| Popis: | Gambling is an addictive disorder with serious societal and personal costs. To-date, there are no approved pharmacological treatments for gambling disorder. Evidence suggests a role for dopamine in gambling disorder and thus may provide a therapeutic target. The present study therefore aimed to investigate the effects of selective antagonists and agonists of D2, D3 and D4 receptors in a rodent analogue of the Iowa gambling task used clinically. In this rat gambling task (rGT), animals are trained to associate different response holes with different magnitudes and probabilities of food pellet rewards and punishing time-out periods. As in the Iowa gambling task, the optimal strategy is to avoid the tempting high-risk high-reward options, and instead favor those linked to smaller per-trial rewards but also lower punishments, thereby maximizing the amount of reward earned over time. Administration of those selective ligands did not affect decision making under the rGT. Only the D4 drug had modest effects on latency measures suggesting that D4 may contribute in some ways to decision making under this task. |
| Databáze: | OpenAIRE |
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