Cellular reaction on the intraperitoneal injection of four types of polylactide particulates
| Autor: | A. van Sliedregt, S. C. Hesseling, C.A. van Blitterswijk, M. Knook, K. de Groot, H. K. Koerten |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Materials science
Neutrophils Ratón Polyesters medicine.medical_treatment Intraperitoneal injection Cell Biophysics chemistry.chemical_element Bioengineering Inflammation Calcium Biomaterials Mice Peritoneal cavity medicine Animals Particle Size Peritoneal Cavity Saline Macrophages Biomaterial Molecular biology Molecular Weight Microscopy Electron medicine.anatomical_structure chemistry Mechanics of Materials Microscopy Electron Scanning Ceramics and Composites medicine.symptom Injections Intraperitoneal Biomedical engineering |
| Zdroj: | Biomaterials. 13:819-824 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/0142-9612(92)90174-m |
| Popis: | Four types of polylactide particulates, P- l -LA 100, 250, 550 KD and a P- dl -LA 400 KD were injected into the peritoneal cavity of mice. The inflammatory reaction showed an increase in cell number (mainly neutrophilic granulocytes) up to 48 h after which the cell numbers decreased below the control (phosphate-buffered saline). All four polylactide particulates aggregated and intermingled with inflammatory cells. The aggregates remained throughout the investigation period of 6 months. Quantitative measurements showed that standardization of the particle form and size is essential. From this study and other experiments in which calcium phosphates and asbestos were injected intraperitoneally, it is concluded that the inflammatory response observed in the peritoneal cavity is related to the type of material injected and probably to form and size of the individual particles, but not to molecular weight. |
| Databáze: | OpenAIRE |
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