Aortic dose constraints when reirradiating thoracic tumors
| Autor: | Justin Rineer, K. Kian Ang, Neal Rebueno, Ritsuko Komaki, Arya Amini, Jaden D. Evans, Daniel R. Gomez, Pamela K. Allen, James W. Welsh, Sarah McAvoy, James D. Cox, Mary K. Martel |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Dose constraints Article medicine.artery medicine Humans Radiology Nuclear Medicine and imaging Lung cancer Aorta Aged Retrospective Studies Thoracic Neoplasm Lung business.industry Cumulative dose Radiotherapy Dosage Retrospective cohort study Hematology Middle Aged Thoracic Neoplasms medicine.disease humanities medicine.anatomical_structure Oncology Toxicity Female Radiology business |
| Zdroj: | Radiotherapy and Oncology. 106:327-332 |
| ISSN: | 0167-8140 |
| Popis: | Improved radiation delivery and planning has allowed, in some instances, for the retreatment of thoracic tumors. We investigated the dose limits of the aorta wherein grade 5 aortic toxicity was observed after reirradiation of lung tumors.In a retrospective analysis, 35 patients were identified, between 1993 and 2008, who received two rounds of external beam irradiation that included the aorta in the radiation fields of both the initial and retreatment plans. We determined the maximum cumulative dose to 1 cm(3) of the aorta (the composite dose) for each patient, normalized these doses to 1.8 Gy/fraction, and corrected them for long-term tissue recovery between treatments (NIDR).The median time interval between treatments was 30 months (range, 1-185 months). The median follow-up of patients alive at analysis was 42 months (range, 14-70 months). Two of the 35 patients (6%) were identified as having grade 5 aortic toxicities. There was a 25% rate of grade 5 aortic toxicity for patients receiving composite doses ≥120.0 Gy (vs. 0% for patients receiving120.0 Gy) (P=0.047).Grade 5 aortic toxicities were observed with composite doses ≥120.0 Gy (NIDR ≥90.0 Gy) to 1cm(3) of the aorta. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect