Hierarchical organization of cortical and thalamic connectivity
| Autor: | Jennifer D. Whitesell, Stephen McConoughey, Yaoyao Li, Yun Wang, Xiuli Kuang, Alex M. Henry, Ali Williford, Quanxin Wang, Amy Bernard, Karla E. Hirokawa, Stefan Mihalas, Robert Howard, Anh Ho, Wayne Wakeman, Maitham Naeemi, David Feng, Peter A. Groblewski, Seung Wook Oh, Leonard Kuan, Nile Graddis, Joseph E. Knox, Benjamin Ouellette, Andrew Cho, Jérôme Lecoq, Hongkui Zeng, Christof Koch, Jennifer Luviano, Hannah Choi, Marty Mortrud, Charles R. Gerfen, Julie A. Harris, Allan R. Jones, Phillip Bohn, Phil Lesnar, Linzy Casal, Shiella Caldejon, Staci A. Sorensen, Lydia Ng, John W. Phillips, Aaron Feiner, Nathalie Gaudreault, Elise Shen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Computer science Thalamus Cre recombinase Projection neuron Article Mice 03 medical and health sciences 0302 clinical medicine Neural Pathways Biological neural network medicine Animals Hierarchical organization Axon Cerebral Cortex Multidisciplinary Computational neuroscience Integrases Axons Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Cortical network Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nature |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | The mammalian cortex is a laminar structure containing many areas and cell types that are densely interconnected in complex ways, and for which generalizable principles of organization remain mostly unknown. Here we describe a major expansion of the Allen Mouse Brain Connectivity Atlas resource1, involving around a thousand new tracer experiments in the cortex and its main satellite structure, the thalamus. We used Cre driver lines (mice expressing Cre recombinase) to comprehensively and selectively label brain-wide connections by layer and class of projection neuron. Through observations of axon termination patterns, we have derived a set of generalized anatomical rules to describe corticocortical, thalamocortical and corticothalamic projections. We have built a model to assign connection patterns between areas as either feedforward or feedback, and generated testable predictions of hierarchical positions for individual cortical and thalamic areas and for cortical network modules. Our results show that cell-class-specific connections are organized in a shallow hierarchy within the mouse corticothalamic network. Using mouse lines in which subsets of neurons are genetically labelled, the authors provide generalized anatomical rules for connections within and between the cortex and thalamus. |
| Databáze: | OpenAIRE |
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