Association of Alport's syndrome with HLA-DR2 antigen in a group of unrelated patients
| Autor: | Júlio César Voltarelli, Tatsuto Kimachi, Eduardo Antônio Donadi, Agenor Spallini Ferraz, Cássia M. Paula-Santos |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Linkage disequilibrium Adolescent Physiology Immunology Biophysics Nephritis Hereditary Human leukocyte antigen Biochemistry Major Histocompatibility Complex Type IV collagen Alport's syndrome Antigen Risk Factors Medicine Humans HLA antigens HLA-DR2 Antigen General Pharmacology Toxicology and Pharmaceutics Allele Child Gene lcsh:QH301-705.5 lcsh:R5-920 business.industry General Neuroscience Cell Biology General Medicine Middle Aged Transplantation immunogenetics lcsh:Biology (General) Relative risk Female MHC business lcsh:Medicine (General) |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 31, Iss 4, p 533 (1998) Brazilian Journal of Medical and Biological Research, Volume: 31, Issue: 4, Pages: 533-537, Published: APR 1998 ResearcherID Brazilian Journal of Medical and Biological Research v.31 n.4 1998 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| ISSN: | 0100-879X |
| Popis: | A few family studies have evaluated HLA antigens in Alport's syndrome; however, there are no large population studies. In the present report, we studied 40 unrelated white patients with Alport's syndrome seen at the Unit of Renal Transplantation, Faculty of Medicine of Ribeirão Preto, São Paulo, Brazil. HLA-A, -B, -DR and -DQ antigens were typed using a complement-dependent microlymphocytotoxicity assay. A control white population (N = 403) from the same geographical area was also typed for HLA antigens. Although the frequencies of HLA-A and -B antigens of patients were not statistically different from controls, the frequency of HLA-DR2 antigen observed in patients (65%) was significantly increased in relation to controls (26%; P |
| Databáze: | OpenAIRE |
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