Validation of functional diffusion maps (fDMs) as a biomarker for human glioma cellularity
| Autor: | Benjamin M. Ellingson, Mark G. Malkin, Carolyn Quinsey, Kathleen M. Schmainda, Jennifer Connelly, Scott D. Rand, Peter S. LaViolette, D. P. Bedekar |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Stereotactic biopsy Radiography Brain tumor Models Biological Sensitivity and Specificity Article White matter Glioma Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Computer Simulation Aged Aged 80 and over medicine.diagnostic_test business.industry Brain Neoplasms Reproducibility of Results Middle Aged medicine.disease Image Enhancement Confidence interval body regions medicine.anatomical_structure Diffusion Magnetic Resonance Imaging Biomarker (medicine) Female business Nuclear medicine Algorithms Diffusion MRI |
| Popis: | Purpose—To present comprehensive examinations of the assumptions made in functional diffusion map (fDM) analyses and provide a biological basis for fDM classification. Materials and Methods—Sixty-nine patients with gliomas were enrolled in this study. To determine the sensitivity of ADC to cellularity, cell density from stereotactic biopsy specimens was correlated with pre-operative ADC maps. For definition of ADC thresholds used for fDMs, the 95% confidence intervals (C.I.) for changes in voxel-wise ADC measurements in normal appearing tissue was analyzed. The sensitivity and specificity to progressing disease was examined using both radiographic and neurological criteria. Results—Results support the hypothesis that ADC is inversely proportional to cell density with a sensitivity of 1.01 × 10 -7 [mm 2 /s]/[nuclei/mm 2 ]. The 95% C.I. for white matter = 0.25×10 -3 mm 2 /s, gray matter = 0.31×10 -3 mm 2 /s, a mixture of white and gray matter = 0.40×10 -3 mm 2 /s, and a mixture of white matter, gray matter, and cerebrospinal fluid = 0.75×10 -3 mm 2 /s. Application of these measurements as ADC thresholds produce varying levels of sensitivity and specificity to disease progression, which were all significantly better than chance. Conclusion—This study suggests fDMs are valid biomarkers for brain tumor cellularity. |
| Databáze: | OpenAIRE |
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