Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression
| Autor: | Moisés Evandro Bauer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Aging Immunology Osteoporosis Review lcsh:Geriatrics 03 medical and health sciences 0302 clinical medicine Antigen medicine Rheumatoid arthritis Immune ageing biology business.industry Autoantibody CD28 Immunosenescence medicine.disease Ageing lcsh:RC952-954.6 030104 developmental biology Cognitive impairment biology.protein Cell senescence Antibody business lcsh:RC581-607 030217 neurology & neurosurgery |
| Zdroj: | Immunity & Ageing, Vol 17, Iss 1, Pp 1-14 (2020) Immunity & Ageing : I & A |
| ISSN: | 1742-4933 |
| DOI: | 10.1186/s12979-020-00178-w |
| Popis: | Patients with rheumatoid arthritis (RA) develop features of accelerated ageing, including immunosenescence. These changes include decreased thymic functionality, expansion of late-differentiated effector T cells, increased telomeric attrition, and excessive production of cytokines (senescence-associated secretory phenotype). The progression of RA has been associated with the early development of age-related co-morbidities, including osteoporosis, cardiovascular complications, and cognitive impairment. Here I review data supporting the hypothesis that immune-senescence contributes to the aggravation of both articular and extra-articular manifestations. Of note, poor cognitive functions in RA were associated with senescent CD28- T cells, inflammaging, and autoantibodies against brain antigens. The pathways of immune-to-brain communication are discussed and provide the rationale for the cognitive impairment reported in RA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |