Resistance of Synthetic and Biologic Surgical Meshes to Methicillin-Resistant

Autor: Laura Nistico, Rachael Kreft, Howard Edington, Frank Cartieri, Barbara Byers, Mark Longwell, Ethan Kallick
Rok vydání: 2018
Předmět:
Zdroj: International Journal of Biomaterials, Vol 2019 (2019)
International Journal of Biomaterials
ISSN: 1687-8787
Popis: Surgical meshes have become the standard procedure for a variety of surgical applications with 20 million meshes being implanted each year. The popularity of mesh usage among surgeons is backed by the multiple studies that support its functionality as a tool for improving surgical outcomes. However, their use has also been associated with infectious surgical complications and many surgeons have turned to biologic meshes. While there have been several studies investigating synthetic meshes, there is limited data comparing synthetic and biologic meshesin vitroin an infection model. This study evaluates thein vitrosusceptibility of both synthetic and biologic meshes to single-species methicillin-resistantStaphylococcus aureus(MRSA) biofilms. This research compares biofilm biomass, average thickness, and coverage between the three meshes throughflorescent in situ hybridization(FISH), confocal scanning microscopy (CSLM), and image analysis. We also report the varying levels of planktonic and attached bacteria through sonication and cfu counts. While the data illustrates increased biofilm formation on biologic meshin vitro, the study must further be investigatedin vivoto confirm the study observations.
Databáze: OpenAIRE
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