Increased risk of herpes zoster in patients with psoriasis: A population-based retrospective cohort study
| Autor: | Yi Ting Chou, Yu Tien Chen, Tse-Yen Yang, Chien Feng Kuo, Hui Ping Ho, Leiyu Shi, Chon Fu Lio, Hsuan Ju Chen, Chi Chen, Fang Ju Sun, Shin-Yi Tsai, Xiaofeng Jia |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Pulmonology lcsh:Medicine Pathology and Laboratory Medicine 030207 dermatology & venereal diseases White Blood Cells 0302 clinical medicine Endocrinology Animal Cells Risk Factors Medicine and Health Sciences Medicine 030212 general & internal medicine lcsh:Science education.field_of_study Multidisciplinary Organic Compounds T Cells Incidence (epidemiology) Hazard ratio Middle Aged 3. Good health Chemistry Hyperlipidemia Cohort Physical Sciences Steroids Female Cellular Types Research Article Adult medicine.medical_specialty Endocrine Disorders Chronic Obstructive Pulmonary Disease Immune Cells Population Immunology Cardiology Taiwan Gastroenterology and Hepatology Herpes Zoster Autoimmune Diseases 03 medical and health sciences Young Adult Signs and Symptoms Diagnostic Medicine Internal medicine Psoriasis Diabetes Mellitus Humans education Retrospective Studies Heart Failure Blood Cells Proportional hazards model business.industry Organic Chemistry Inflammatory Bowel Disease lcsh:R Chemical Compounds Biology and Life Sciences Retrospective cohort study Cell Biology medicine.disease Confidence interval Metabolic Disorders Clinical Immunology lcsh:Q Clinical Medicine business |
| Zdroj: | PLoS ONE, Vol 12, Iss 8, p e0179447 (2017) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Objectives The risk of herpes zoster (HZ) between patients with psoriasis receiving and not receiving systemic therapy has received increasing attention. This study investigated the association of psoriasis with the risk of HZ. Methods We conducted a population-based retrospective cohort study by using the Taiwan National Health Insurance Research Database. The psoriasis cohort consisted of 4077 patients with newly diagnosed psoriasis between 2000 and 2006. Each patient with psoriasis was frequency-matched with four people without psoriasis, by sex, age and index year. (nonpsoriasis cohort; 16308 subjects). Patients who received systemic therapy were classified as having severe psoriasis, whereas those who did not receive systemic therapy were classified as having mild psoriasis. The Cox proportional hazards regression analysis was conducted to estimate the association between psoriasis and HZ risk. Results The overall incidence density rate of HZ in the psoriasis cohort than in the nonpsoriasis cohort (4.50 vs. 3.44 per 1,000 person-years), with a multivariable Cox proportional hazards model measured adjusted HR of 1.29 [95% confidence interval (CI) = 1.07–1.56]. In additional, compared with the nonpsoriasis cohort, the risk of HZ was higher in the severe psoriasis cohort than in the nonpsoriasis cohort (adjusted hazard ratio [HR], 1.61; 95% confidence interval [CI], 1.15–2.27). The comparison between psoriasis and nonpsoriasis cohorts revealed a greatest magnitude risk of HZ in women (adjusted HR, 1.36; 95% CI, 1.04–1.79), study participants in the age group of 20–39 years (adjusted HR, 1.77; 95% CI, 1.17–2.66), and study participants without any comorbidities (adjusted HR, 1.37; 95% CI, 1.02–1.84). Conclusions Our results suggest that psoriasis is associated with an increased risk of HZ, which involves differences in sex and age. Although systemic therapy may have a major role in the risk of HZ, the intrinsic factors of psoriasis cannot be excluded. |
| Databáze: | OpenAIRE |
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