Facilitation as well as inhibition of the blink reflex by a visual prepulse requires intact striate cortex
| Autor: | Lenworth N. Johnson, Anita J. Jurkowski, Steven A. Hackley, Douglas Sonnenberg |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent genetic structures Blindsight Clinical neurophysiology Physiology (medical) Reaction Time medicine Humans Corneal reflex Latency (engineering) Prepulse inhibition Aged Visual Cortex Blinking Electromyography Neural Inhibition Middle Aged Sensory Systems Electrooculography medicine.anatomical_structure Visual cortex Neurology Brain Injuries Facilitation Female Human eye Neurology (clinical) Psychology Neuroscience |
| Zdroj: | Clinical Neurophysiology. 117:2284-2291 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2006.05.020 |
| Popis: | Objective: The role of visual cortex in modulation of the human eye blink reflex was assessed. Methods: Participants were 13 patients with unilateral striate cortex damage. Nonreflexogenic gratings were presented in their intact or blind hemifield prior to white noise or air puff blink-eliciting stimuli. Results: Inhibition of reflex amplitude was observed at asynchronies ranging from about 120 to 600 ms for visible but not invisible prepulses. Facilitation by intact-hemifield gratings was observed for (1) the latency of the acoustic blink reflex, (2) the amplitude of the disynaptic cutaneous blink reflex, R1, and (3) the latency of voluntary hand-grip reactions to the reflexogenic stimuli. These facilitatory effects were absent on trials with blind-hemifield prepulses. Conclusions: An intact V1 is required for prepulse facilitation as well as inhibition. Significance: These results extend a popular model of sensorimotor gating deficits in schizophrenia. 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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