Potential drug-drug interactions among elderly patients on anti-hypertensive medications in two tertiary healthcare facilities in Ekiti State, South-West Nigeria
| Autor: | Joseph O Fadare, S.M. Agboola, Adekunle Olaitan Adeoti, Olufemi Olumuyiwa Desalu, Adekunle E Ajayi, Abimbola M. Obimakinde |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Drug Utilization
medicine.medical_specialty drug-drug interactions lcsh:Medicine Context (language use) 030204 cardiovascular system & hematology Anti-hypertensive medications 03 medical and health sciences 0302 clinical medicine Hydrochlorothiazide Internal medicine medicine Outpatient clinic 030212 general & internal medicine polypharmacy Intensive care medicine Polypharmacy business.industry lcsh:R Lisinopril geriatric patients General Medicine Drug interaction business drug utilization Combination drug medicine.drug |
| Zdroj: | Sahel Medical Journal, Vol 19, Iss 1, Pp 32-37 (2016) |
| ISSN: | 2321-6689 |
| Popis: | Introduction: Drug-drug interactions remain a major cause of adverse drug reactions with great consequences such as increased morbidity and increased healthcare cost. In elderly patients with systemic hypertension, there is a tendency for them to be prescribed multiple medications and this may expose them to some drug-drug interactions (DDIs) especially in the context of physiological changes of ageing. The objective of this study was to evaluate potential drug-drug interaction among some Nigerian elderly hypertension. Methods: A cross-sectional study involving elderly hypertensive patients attending the general outpatient clinic of two tertiary healthcare facilities located in Ekiti State, South-West Nigeria. The information collected from the patients' medical records included their ages, gender, diagnosis and list of prescribed anti-hypertensive medications. Potential drug-drug interactions were checked for using the Multi-Drug Interaction Checker (Medscape Reference) and Epocrates Drug Interaction Checker (San Mateo CA, USA). Results: A total of 350 elderly patients attended the clinics during the study period of which 208 (59.4%) hypertensive patients were identified and their records used for analysis. The fixed-dose combination drug Moduretic® (Amiloride /Hydrochlorothiazide)-25.7% was the most commonly prescribed antihypertensive followed by Lisinopril (16.6%), Amlodipine (13.2%) and Nifedipine (12.6%). The anti-platelet Acetyl-salicylic acid (ASA) was prescribed for 100 (48.1%) patients and represented 19.8% of all prescribed medications. A total of 231 potential DDIs were found among the patients giving a mean of 1.3 interactions per patient. The most common identified drug pairs with potential interactions were ACE inhibitors - Amiloride, followed by ACE inhibitors - Hydrochlorothiazide, ACE inhibitors - ASA and ARB - Amiloride. Conclusion: Potential drug-drug interactions, though common in this study comprised mainly of minor and moderate types. Notwithstanding, physicians need to be reminded of the potential for interactions when prescribing for elderly patients |
| Databáze: | OpenAIRE |
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