Ranibizumab monotherapy versus single-session verteporfin photodynamic therapy combined with as-needed ranibizumab treatment for the management of neovascular age-related macular degeneration
| Autor: | Alex R Schakal, Ziad F. Bashshur, Georges M. El-Mollayess, Haytham I. Salti, Samer N. Arafat, Dalida Jaafar |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Porphyrins Time Factors genetic structures Combination therapy medicine.medical_treatment Visual Acuity Photodynamic therapy Antibodies Monoclonal Humanized Retina Ophthalmology Age related Ranibizumab medicine Humans Prospective Studies Fluorescein Angiography Aged Photosensitizing Agents business.industry Verteporfin General Medicine Macular degeneration medicine.disease Combined Modality Therapy eye diseases Treatment Outcome Photochemotherapy Intravitreal Injections Retreatment Wet Macular Degeneration Female sense organs Intravitreal ranibizumab business Single session Tomography Optical Coherence medicine.drug |
| Zdroj: | Retina (Philadelphia, Pa.). 31(4) |
| ISSN: | 1539-2864 |
| Popis: | To compare verteporfin photodynamic therapy combined with intravitreal ranibizumab (combination therapy) versus ranibizumab monotherapy for management of neovascular age-related macular degeneration.Thirty patients (40 eyes) with neovascular age-related macular degeneration were prospectively allocated to combination therapy or monotherapy. In monotherapy, the induction phase consisted of 3 consecutive monthly ranibizumab injections (0.5 mg), while the combination therapy had a single session of photodynamic therapy with intravitreal ranibizumab. Follow-up treatment for either group consisted only of additional as-needed ranibizumab injections. The main outcome measure was that a proportion of eyes losing15 letters of visual acuity after 12 months.Except for 1 eye in combination therapy, all eyes in both groups lost15 letters of visual acuity. At 12 months, there was a mean gain of +12 letters and +3.2 letters for monotherapy and combination therapy, respectively (relative percent change of 32% vs. 7%, P = 0.03). Anatomical improvement was similar in both groups. After induction, the time until ranibizumab retreatment was longer for combination therapy (P = 0.002) while ranibizumab injections were required more frequently with monotherapy (P = 0.015).Ranibizumab monotherapy showed greater improvement in visual acuity versus combination therapy. However, combination therapy required fewer ranibizumab injections. Larger trials need to confirm the findings of this pilot study. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|