Dual-drug delivery of Ag-chitosan nanoparticles and phenytoin via core-shell PVA/PCL electrospun nanofibers

Autor: Erkan Rayaman, Demet Sezgin Mansuroglu, Ali Sahin, Oguzhan Gunduz, Mamoun Muhammed, Ibrahim M. El-Sherbiny, Mosaad Megahed, Mohamed Ahmed Mohamady Hussein, Mariusz Grinholc, Muhammet Emin Cam, Yesim Muge Sahin, Ece Guler
Rok vydání: 2021
Předmět:
Staphylococcus aureus
Silver
Materials science
Polymers and Plastics
Polyesters
Nanofibers
02 engineering and technology
010402 general chemistry
01 natural sciences
Polyvinyl alcohol
Silver nanoparticle
Chitosan
chemistry.chemical_compound
Drug Delivery Systems
Spectroscopy
Fourier Transform Infrared
Escherichia coli
Materials Chemistry
Core-Shell Nanofibers
Cell Proliferation
Wound Healing
Calorimetry
Differential Scanning
integumentary system
Dual-Drug Delivery
Organic Chemistry
technology
industry
and agriculture
Biomaterial
021001 nanoscience & nanotechnology
Anti-Bacterial Agents
0104 chemical sciences
Membrane
chemistry
Chemical engineering
Polyvinyl Alcohol
Phenytoin
Nanofiber
Drug delivery
Polycaprolactone
Microscopy
Electron
Scanning
Nanoparticles
Silver Nanoparticles
0210 nano-technology
Zdroj: Carbohydrate Polymers. 270:118373
ISSN: 0144-8617
DOI: 10.1016/j.carbpol.2021.118373
Popis: Dual-drug delivery systems were constructed through coaxial techniques, which were convenient for the model drugs used the present work. This study aimed to fabricate core-shell electrospun nanofibrous membranes displaying simultaneous cell proliferation and antibacterial activity. For that purpose, phenytoin (Ph), a well-known proliferative agent, was loaded into a polycaprolactone (PCL) shell membrane, and as-prepared silver-chitosan nanoparticles (Ag-CS NPs), as biocidal agents, were embedded in a polyvinyl alcohol (PVA) core layer. The morphology, chemical composition, mechanical and thermal properties of the nanofibrous membranes were characterized by FESEM/STEM, FTIR and DSC. The coaxial PVA-Ag CS NPs/PCL-Ph nanofibers (NFs) showed more controlled Ph release than PVA/PCL-Ph NFs. There was notable improvement in the morphology, thermal, mechanical, antibacterial properties and cytobiocompatibility of the fibers upon incorporation of Ph and Ag-CS NPs. The proposed core-shell PVA/PCL NFs represent promising scaffolds for tissue regeneration and wound healing by the effective dual delivery of phenytoin and Ag-CS NPs.
Databáze: OpenAIRE
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