| Autor: |
Natalie Mitchell, Vanessa Quinn, Keith Couper, Jean Antonelli, Lia McNamee, Janice Montgomery, Akesh Dhrampal, Alison Hall, Ronald Carrera, Henrik Reschreiter, Samantha Hendry, Stephen T. Webb, Maurizio Cecconi, Teresa Melody, Jonathan Hackett, Emer Neau, Peter Hampshire, Sarah Hierons, Gareth Sellors, Zoe Beardow, Ron Daniels, Pratik Sinha, Colette Seasman, Dawn Kelly, Carolyn S. Calfee, Katarzyna Zamoscik, Mike Gillies, Chris Smalley, Fiona Wade-Smith, Stephen G. Ward, Carole Schilling, Alexander Binning, Cecilia O'Kane, Kulwant Dhadwal, Timothy S. Walsh, Laura Youds, Lisa Sleight, Clair Harris, Pam Ramsay, Aisling Clarkson, Stephen Drage, Amy McInerney, Murthy Buddhavarapu, Kirsty Everingham, J A Wood, Daniel Martin, Kayla Harris, Corrienne McCulloch, Cliona McDowell, Griania White, Dorothy Breen, Julie Dawson, David Rogerson, Luigi Camporota, Kallirroi Kefala, John G Laffey, Brian Marsh, Archana Paikray, Lynn Gilfeather, Andrew Burtenshaw, Kevin L. Delucchi, Kate McGuigan, David Hope, Syed Farjad Sultan, Abby Brown, Sinead O'Kane, Melissa Rosbergen, Paula Meale, Daniel F. McAuley, Anna Walker, Julie Patrick-Heselton, Noel Hemmings, Sarah James, Arlo Whitehouse, Willis J Peel, Michael A. Matthay, Louise Boardman, Julie Wollaston, John G. Laffey, Sundeep Kaul, Andrew Gratrix, Paul Jefferson, Ged Dempsey, David Shaw, Alistair Nichol, Daniel Hadfield, Veronica McInerney, Ingeborg Welters, Katie Sweet, Samantha Hagan, Conor Bentley, Karen Williams, Tom Trinick, Manu Shankar-Hari, Heidi Dawson, Andrew Johnston, Stephen Graystone, Daniel McAuley, Banwari Agarwal, Julie Camsooksai, Victoria Martinson, Catherine Jardine, Andrew R Bodenham, Prashast Prashast, James O'Rourke, Clare Mellis, Fang Gao, Craig Morris, Neil Young, Steven Henderson, Victoria Waugh, Christopher Danbury, Yongyan Qui, Georgina Parsons, Catherine Leonard, Neil Smith, Timothy Gould, Molly Chibvuri, Nicola Jacques, Sinead Helyar, Matthew Thomas, Sarah Casboult, Lukas Pokorny, Alan Davidson, Naomi Hickey, Rachael Bennett, Joanne Thompson, Orla O'Neill, Elizabeth Lemon, Paul Johnston, Cat Yates, John Trinder, Gavin Nicol, Jacqueline Baldwin, Johannes Mellinghoff, Philip Hopkins, Julian Hull, Helena Barcraft-Barnes, Lee Poole, Fiona Bottrill, Jessica Thrush, Anissa Benchiheub, Stuart Elliot, Fiona Pollock, Lauren Cooper, Grant Price, Teresa Martin, Leona Bannon, Sian Birch, Reni Jacob, Terry Martin, Gavin D. Perkins, Geraldine Ward, Donal Ryan, Esther Price, Petra Polgarova, Agnieszka Walecka, Katie Lei, Chris Nutt, Christopher Bassford, Laura Ortiz-Ruiz de Gordoa, Irfan Chaudry, Stephen E Wright |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Irish Critical Care Trials Group 2018, ' Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial ', The Lancet Respiratory Medicine, vol. 6, no. 9, pp. 691-698 . https://doi.org/10.1016/S2213-2600(18)30177-2
Calfee, C, Delucchi, K, Sinha, P, Matthay, M, Hackett, J, Shankar-Hari, M, McDowell, C, G. Laffey, J, O’Kane, C & McAuley, D F 2018, ' Acute respiratory distress syndrome subphenotypes and differential response to simvastatin : Secondary Analysis of a Randomized Controlled Trial ', The lancet. Respiratory medicine . https://doi.org/10.1016/S2213-2600(18)30177-2 |
| DOI: |
10.1016/S2213-2600(18)30177-2 |
| Popis: |
Background: Precision medicine approaches targeting patients based on disease subtype have transformed approaches to cancer, asthma, and other heterogeneous syndromes. Two distinct subphenotypes of ARDS have been identified in three US-based clinical trials and respond differently to positive end-expiratory pressure and fluid management. It remains unknown if these subphenotypes exist in different populations and respond differently to pharmacotherapies. Methods: We conducted a secondary analysis using data from 539 patients enrolled in a UK multicenter, placebo-controlled randomized trial of simvastatin for ARDS (HARP-2). Latent class analysis was applied to baseline data without consideration of outcomes to identify subphenotypes. Clinical outcomes were compared across subphenotypes and treatment groups. Findings: A two class (two-subphenotype) model was an improvement over a one class model (pInterpretation: Two subphenotypes of ARDS were identified in the HARP-2 cohort, withdistinct clinical and biological features and disparate clinical outcomes; the hyper-inflammatory subphenotype had improved survival with simvastatin compared to placebo. These findings support further pursuit of predictive enrichment strategies in critical care clinical trials. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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