Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer†
| Autor: | Julia S. Johansen, Hans Jørgen Nielsen, Emilie Hammer, Martin H. Hvolris, Lars N. Jorgensen, Nils Brünner, Jesper Olsen, Knud T. Nielsen, Gerard J. Davis, Søren Laurberg, Thomas B. Piper, Ib Jarle Christensen, Barry L. Dowell, Hans B Rahr |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Colorectal cancer Tissue Inhibitor of Metalloproteinase-1/blood Intestinal Neoplasms/pathology Colonoscopy Gastroenterology Endoscopy Gastrointestinal CEA 0302 clinical medicine Prospective Studies Colorectal Neoplasms/blood Aged 80 and over Antigens Tumor-Associated Carbohydrate/blood medicine.diagnostic_test Middle Aged CA19-9 030220 oncology & carcinogenesis Biomarker (medicine) Female 030211 gastroenterology & hepatology Colorectal Neoplasms Adult medicine.medical_specialty YKL-40 colorectal cancer Diverticulum Colon Malignancy diverticula 03 medical and health sciences TIMP-1 Diverticulum Colon/diagnosis Internal medicine Intestinal Neoplasms CA19-9 CEA colorectal cancer diverticula endoscopy malignancy TIMP-1 YKL-40 c-reactive protein primary colorectal-cancer diverticular-disease uncomplicated diverticulitis plasma timp-1 population individuals ykl-40 tests cea Gastroenterology & Hepatology Biomarkers Tumor medicine Humans Antigens Tumor-Associated Carbohydrate Chitinase-3-Like Protein 1 endoscopy Aged Retrospective Studies Tissue Inhibitor of Metalloproteinase-1 business.industry Cancer Retrospective cohort study medicine.disease digestive system diseases Endoscopy Chitinase-3-Like Protein 1/blood Biomarkers Tumor/blood business malignancy |
| Zdroj: | Hvolris, M H, Piper, T B, Hammer, E, Jorgensen, L N, Olsen, J, Rahr, H B, Nielsen, K T, Laurberg, S, Christensen, I J, Brunner, N, Johansen, J S, Davis, G J, Dowell, B L & Nielsen, H J 2016, ' Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer ', Scandinavian Journal of Gastroenterology, vol. 51, no. 7, pp. 860-865 . https://doi.org/10.3109/00365521.2016.1144783 Hvolris, M H, Piper, T B, Hammer, E, Jørgensen, L N, Olsen, J, Rahr, H B, Nielsen, K T, Laurberg, S, Christensen, I J, Brünner, N, Johansen, J S, Davis, G J, Dowell, B L & Nielsen, H J 2016, ' Increased serological cancer-associated biomarker levels at large bowel endoscopy and risk of subsequent primary cancer (†) ', Scandinavian Journal of Gastroenterology, vol. 51, no. 7, pp. 860-5 . https://doi.org/10.3109/00365521.2016.1144783 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | Background: Frequently, subjects offered colonoscopy due to symptoms of colorectal neoplasia are diagnosed with diverticula. The symptoms may, however, also be related to extra-colonic neoplasia. The present retrospective study evaluated a possible association between increased levels of predefined biomarkers in subjects diagnosed with diverticula and risk of developing a primary malignant disease. Methods: During 2004/2005, about 4509 subjects were included in a multicenter study with collection of blood samples before bowel endoscopy. The aim was to evaluate a relation between the protein biomarkers CEA, TIMP-1, CA19-9 and YKL-40 and findings at endoscopy. Diverticula were diagnosed in 1021 subjects. By 31 December 2012, subjects who had developed primary malignancy were identified retrospectively and relation between biomarker levels at endoscopy and risk of developing primary malignancy was calculated. The relation with the four biomarkers was divided into three groups: 0 = none increased; 1 = one increased and 2 = two or more increased. Results: In the observation period, 148 subjects developed a primary malignant disease. Univariable analyzes of the biomarker levels showed that CEA, TIMP-1 and CA19-9 were significantly associated with development of primary malignancy. A multivariable analysis showed that increased levels were associated with development of malignancy (p< 0.0001). The 1-and 5-year cumulative risks of being diagnosed with a primary malignancy were: group 0: 1.1%/5.5%; group 1: 4.2%/10.1% and group 2: 11.4%/18.8%, respectively. Conclusion: Increased levels of CEA, TIMP-1 and CA19-9 at endoscopy with findings of diverticula were associated with a significantly increased risk of being diagnosed with a subsequent primary malignant disease. Background: Frequently, subjects offered colonoscopy due to symptoms of colorectal neoplasia are diagnosed with diverticula. The symptoms may, however, also be related to extra-colonic neoplasia. The present retrospective study evaluated a possible association between increased levels of predefined biomarkers in subjects diagnosed with diverticula and risk of developing a primary malignant disease. Methods: During 2004/2005, about 4509 subjects were included in a multicenter study with collection of blood samples before bowel endoscopy. The aim was to evaluate a relation between the protein biomarkers CEA, TIMP-1, CA19-9 and YKL-40 and findings at endoscopy. Diverticula were diagnosed in 1021 subjects. By 31 December 2012, subjects who had developed primary malignancy were identified retrospectively and relation between biomarker levels at endoscopy and risk of developing primary malignancy was calculated. The relation with the four biomarkers was divided into three groups: 0 = none increased; 1 = one increased and 2 = two or more increased. Results: In the observation period, 148 subjects developed a primary malignant disease. Univariable analyzes of the biomarker levels showed that CEA, TIMP-1 and CA19-9 were significantly associated with development of primary malignancy. A multivariable analysis showed that increased levels were associated with development of malignancy (p< 0.0001). The 1-and 5-year cumulative risks of being diagnosed with a primary malignancy were: group 0: 1.1%/5.5%; group 1: 4.2%/10.1% and group 2: 11.4%/18.8%, respectively. Conclusion: Increased levels of CEA, TIMP-1 and CA19-9 at endoscopy with findings of diverticula were associated with a significantly increased risk of being diagnosed with a subsequent primary malignant disease. |
| Databáze: | OpenAIRE |
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