Delayed Hypersensitivity in Primary and Secondary Hyperparathyroidism. Treatment with Active Vitamin D
| Autor: | Lars Lind, B. Wengle, Sverker Ljunghall, O. H. Sörensen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Vitamin
medicine.medical_specialty Calcitriol Endocrinology Diabetes and Metabolism chemistry.chemical_compound Endocrinology Double-Blind Method Internal medicine Immunopathology Internal Medicine medicine Vitamin D and neurology Humans Hypersensitivity Delayed Vitamin D Immunity Cellular Hyperparathyroidism Tuberculin Test business.industry General Medicine medicine.disease chemistry Delayed hypersensitivity Kidney Failure Chronic Secondary hyperparathyroidism business Primary hyperparathyroidism medicine.drug |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 95:271-274 |
| ISSN: | 1439-3646 0947-7349 |
| Popis: | The vitamin D endocrine system, besides its traditional role in mineral metabolism, also affects the immune system. A recent study demonstrated that vitamin D supplementation restored a blunted delayed hypersensitivity response (DH) in elderly vitamin D-deficient subjects. In the present study the DH, as measured by the tuberculin test (PPD), was studied in two groups of patients with a disturbed vitamin D system, i.e. primary hyperparathyroidism (HPT) and secondary HPT due to chronic renal failure. A significant reduction in DH was found in the patients with chronic renal failure when compared to control subjects (4.1 +/- 5.3 vs 12 +/- 9.3 mm, p less than 0.05) whereas only a non-significant tendency to a reduced DH was seen in the HPT patients (9.5 +/- 9.2 mm). Treatment with alphacalcidol, a synthetic analogue to the active vitamin D metabolite over 3-6 months did not affect the DH in any of the hyperparathyroid patient groups. Thus it seems likely that other factors than vitamin D were involved in their reduced DH response. |
| Databáze: | OpenAIRE |
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