Hematopoietic recovery following autologous bone marrow transplantation: Role of cryopreservation, number of cells infused and nature of high-dose chemotherapy
| Autor: | Jean Lemerle, F. Beaujean, S. Bayet, Claude Parmentier, Tournade Mf, Jose-Luis Pico, Olivier Hartmann |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Melphalan Pathology medicine.medical_specialty Adolescent Lymphocyte medicine.medical_treatment Urology Cell Count Granulocyte Cryopreservation Leukocyte Count Neoplasms Freezing medicine Humans Lymphocytes Child Bone Marrow Transplantation Chemotherapy business.industry Infant Hematopoietic Stem Cells Combined Modality Therapy Hematopoiesis Transplantation Haematopoiesis medicine.anatomical_structure Oncology Child Preschool Erythrocyte Count Female Bone marrow business medicine.drug |
| Zdroj: | European Journal of Cancer and Clinical Oncology. 21:53-60 |
| ISSN: | 0277-5379 |
| DOI: | 10.1016/0277-5379(85)90200-7 |
| Popis: | Twenty-nine patients were treated with single or combined high-dose melphalan therapy followed by autologous bone marrow transplantation. Hematopoietic recovery from these treatments was studied. No correlation was found between the number of GM-CFC infused and the time required for hematopoietic recovery. It is suggested that this correlation is only demonstrable for low ‘doses’ of infused bone marrow cell and/ or GM-CFCs. The role of bone marrow cell preservation techniques was examined and results were similar for fresh and cryopreserved bone marrow. The erythrocyte, lymphocyte and granulocyte levels of the patients reported here reached a normal or subnormal hematological steady state 3 months after autograft. Our results confirm the value of cryopreservation techniques. Hematopoietic recovery was short and of the same duration whether the patients were given single or combined high-dose melphalan before autologous bone marrow transplantation. These results also demonstrate the value of such transplantation in shortening the myelosuppression caused by high-dose chemotherapy. |
| Databáze: | OpenAIRE |
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