Poly(ethylene carbonate): a thermoelastic and biodegradable biomaterial for drug eluting stent coatings?
| Autor: | Ralf Wombacher, Phillip Hanefeld, Ullrich Westedt, Michael Ausborn, S. Zimmermann, Florian Unger, Thomas Kissel, Andreas Greiner |
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| Rok vydání: | 2006 |
| Předmět: |
Materials science
Biocompatibility Chemical Phenomena Paclitaxel Scanning electron microscope Cell Survival medicine.medical_treatment Pharmaceutical Science Biocompatible Materials engineering.material chemistry.chemical_compound Mice Coating X-Ray Diffraction Tensile Strength medicine Animals Ethylene carbonate Biotransformation chemistry.chemical_classification Calorimetry Differential Scanning Chemistry Physical Biomaterial Polymer Fibroblasts Antineoplastic Agents Phytogenic Elasticity Molecular Weight chemistry Chemical engineering Drug-eluting stent engineering Chromatography Gel Microscopy Electron Scanning Stents Polyethylenes |
| Zdroj: | Journal of controlled release : official journal of the Controlled Release Society. 117(3) |
| ISSN: | 0168-3659 |
| Popis: | A first feasibility study exploring the utility of poly(ethylene carbonate) (PEC) as coating material for drug eluting stents under in vitro conditions is reported. PEC (Mw 242 kDa, Mw/Mn = 1.90) was found to be an amorphous polymer with thermoelastic properties. Tensile testing revealed a stress to strain failure of more than 600%. These properties are thought to be advantageous for expanding coated stents. In vitro cytotoxicity tests showed excellent cytocompatibility of PEC. Based on these findings, a new stenting concept was suggested, pre-coating a bare-metal stent with PPX-N as non-biodegradable basis and applying a secondary PEC coating using an airbrush method. After manual expansion, no delamination or destruction of the coating could be observed using scanning electron microscopy. The surface degradation-controlled release mechanism of PEC may provide the basis for “on demand” drug eluting stent coatings, releasing an incorporated drug predominantly at an inflamed implantation site upon direct contact with superoxide-releasing macrophages. As a release model, metal plates of a defined size and area were coated under the same conditions as the stents with PEC containing radiolabelled paclitaxel. An alkaline KO2− solution served as a superoxide source. Within 12 h, 100% of the incorporated paclitaxel was released, while only 20% of the drug was released in non-superoxide releasing control buffer within 3 weeks. |
| Databáze: | OpenAIRE |
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