High-Dose Ursodeoxycholic Acid Is Associated With the Development of Colorectal Neoplasia in Patients With Ulcerative Colitis and Primary Sclerosing Cholangitis
| Autor: | Emmanouil Sinakos, M. Edwyn Harrison, Timothy M. McCashland, Kris V. Kowdley, Marina G. Silveira, Darrell S. Pardi, Jan Petz, Velimir A. Luketic, John E. Eaton, Alex S. Befeler, Keith D. Lindor, Roberta A. Jorgensen, Denise M. Harnois |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Risk Cholagogues and Choleretics medicine.medical_specialty Lithocholic acid Adolescent Cholangitis Sclerosing Chenodeoxycholic Acid Gastroenterology Primary sclerosing cholangitis Young Adult chemistry.chemical_compound Chenodeoxycholic acid Internal medicine medicine Humans Colitis Young adult Aged Proportional Hazards Models Retrospective Studies Hepatology business.industry Ursodeoxycholic Acid Retrospective cohort study Middle Aged medicine.disease Ulcerative colitis Ursodeoxycholic acid chemistry Colitis Ulcerative Female Lithocholic Acid Colorectal Neoplasms business Follow-Up Studies medicine.drug |
| Zdroj: | American Journal of Gastroenterology. 106:1638-1645 |
| ISSN: | 0002-9270 |
| DOI: | 10.1038/ajg.2011.156 |
| Popis: | Some studies have suggested that ursodeoxycholic acid (UDCA) may have a chemopreventive effect on the development of colorectal neoplasia in patients with ulcerative colitis (UC) and primary sclerosing cholangitis (PSC). We examined the effects of high-dose (28-30 mg/kg/day) UDCA on the development of colorectal neoplasia in patients with UC and PSC.Patients with UC and PSC enrolled in a prior, multicenter randomized placebo-controlled trial of high-dose UDCA were evaluated for the development of colorectal neoplasia. Patients with UC and PSC who received UDCA were compared with those who received placebo. We reviewed the pathology and colonoscopy reports for the development of low-grade or high-grade dysplasia or colorectal cancer.Fifty-six subjects were followed for a total of 235 patient years. Baseline characteristics (including duration of PSC and UC, medications, patient age, family history of colorectal cancer, and smoking status) were similar for both the groups. Patients who received high-dose UDCA had a significantly higher risk of developing colorectal neoplasia (dysplasia and cancer) during the study compared with those who received placebo (hazard ratio: 4.44, 95% confidence interval: 1.30-20.10, P=0.02).Long-term use of high-dose UDCA is associated with an increased risk of colorectal neoplasia in patients with UC and PSC. |
| Databáze: | OpenAIRE |
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