Medical oncologists' perspectives of the Veterans Affairs National Precision Oncology Program

Autor: Dilhan Weeraratne, Jill E. Duffy, Gretchen Purcell Jackson, Pradeep J. Poonnen, Vishal Vashistha, Jane L. Snowdon, Victoria McCaffrey, Vimla L. Patel, Bradley J. Hintze, Halcyon G. Skinner, Neil L Spector, Michael J. Kelley
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Health Knowledge
Attitudes
Practice
Molecular biology
Cancer Treatment
Metastasis
0302 clinical medicine
Sequencing techniques
Neoplasms
Surveys and Questionnaires
Basic Cancer Research
Medicine and Health Sciences
Medicine
Sampling (medicine)
DNA sequencing
Medical Personnel
Precision Medicine
Early Detection of Cancer
Oncologists
Multidisciplinary
High-Throughput Nucleotide Sequencing
Genomics
Middle Aged
Test (assessment)
United States Department of Veterans Affairs
Professions
Oncology
030220 oncology & carcinogenesis
Female
Thematic analysis
Transcriptome Analysis
Research Article
Adult
Next-Generation Sequencing
medicine.medical_specialty
Science
State Health Plans
MEDLINE
03 medical and health sciences
Malignant Tumors
Genetics
Humans
Genetic Testing
Veterans Affairs
Biology and life sciences
business.industry
Cancers and Neoplasms
Computational Biology
Sequence Analysis
DNA
Genome Analysis
United States
Research and analysis methods
Pathologists
030104 developmental biology
Molecular biology techniques
Summative assessment
Precision oncology
Family medicine
People and Places
Population Groupings
Open coding
business
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 7, p e0235861 (2020)
ISSN: 1932-6203
Popis: BackgroundTo support the rising need for testing and to standardize tumor DNA sequencing practices within the U.S. Department of Veterans Affairs (VA)'s Veterans Health Administration (VHA), the National Precision Oncology Program (NPOP) was launched in 2016. We sought to assess oncologists' practices, concerns, and perceptions regarding Next-Generation Sequencing (NGS) and the NPOP.Materials and methodsUsing a purposive total sampling approach, oncologists who had previously ordered NGS for at least one tumor sample through the NPOP were invited to participate in semi-structured interviews. Questions assessed the following: expectations for the NPOP, procedural requirements, applicability of testing results, and the summative utility of the NPOP. Interviews were assessed using an open coding approach. Thematic analysis was conducted to evaluate the completed codebook. Themes were defined deductively by reviewing the direct responses to interview questions as well as inductively by identifying emerging patterns of data.ResultsOf the 105 medical oncologists who were invited to participate, 20 (19%) were interviewed from 19 different VA medical centers in 14 states. Five recurrent themes were observed: (1) Educational Efforts Regarding Tumor DNA Sequencing Should be Undertaken, (2) Pathology Departments Share a Critical Role in Facilitating Test Completion, (3) Tumor DNA Sequencing via NGS Serves as the Most Comprehensive Testing Modality within Precision Oncology, (4) The Availability of the NPOP Has Expanded Options for Select Patients, and (5) The Completion of Tumor DNA Sequencing through the NPOP Could Help Improve Research Efforts within VHA Oncology Practices.ConclusionMedical oncologists believe that the availability of tumor DNA sequencing through the NPOP could potentially lead to an improvement in outcomes for veterans with metastatic solid tumors. Efforts should be directed toward improving oncologists' understanding of sequencing, strengthening collaborative relationships between oncologists and pathologists, and assessing the role of comprehensive NGS panels within the battery of precision tests.
Databáze: OpenAIRE
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