Analysis of virulence proteins in pathogenic Acinetobacter baumannii to provide early warning of zoonotic risk

Autor: Deying Zou, Jiang Chang, Shiying Lu, Jianfeng Xu, Pan Hu, Kai Zhang, Xiaoli Sun, Wei Guo, Yansong Li, Zengshan Liu, Honglin Ren
Rok vydání: 2023
Předmět:
Zdroj: Microbiological Research. 266:127222
ISSN: 0944-5013
DOI: 10.1016/j.micres.2022.127222
Popis: Acinetobacter baumannii is a ubiquitous opportunistic pathogen usually with low virulence. In recent years, reports of increased pathogenicity of A. baumannii in livestock due to the migratory behaviour of wildlife have attracted public health attention. Our previous study reported that an A. baumannii strain isolated from dead chicks, CCGGD201101, showed enhanced pathogenicity, but the mechanism for increased virulence is not understood. Here, to screen potential virulence factors, the proteomes of the isolated strain CCGGD201101 and the standard strain ATCC19606 of A. baumannii were compared, and the possible virulence-enhancing mechanisms were further analysed. The 50 % lethal dose (LD
Databáze: OpenAIRE